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22 August 2019 | Story Eugene Seegers
Simonè Nel (Read More)
“When looking at the simply amazing female leadership emerging at the UFS — academic as well as administrative — I see hope and growth,” says Simoné Nel, a member of the management team on the South Campus.

Simoné Nel heads up the Support Services division on the UFS South Campus. Despite challenges during her youth, she learnt the power of strong examples to look up to, and still lives by the mantra she learnt in primary school from her Drum Majorettes coach. She believes that inspiration can come from mundane sources, day-to-day conversations, or even her children; she is the mother of a 10-year-old son and a 7-year-old daughter. In fact, her best example of teamwork comes from her experiences as mother: “Just watch what happens when a mother is calling frantically for her child if he slips from her grip; EVERYONE helps to find him!”

Tell us about your childhood: What are some of the lessons you learned early on? 

Growing up in the Western Cape, I had a primary school teacher and coach who taught me the value of the saying: “It is not the hours you put in, but what you put into the hours.” I still live by this; trying to make the most of every hour. Both of my parents passed away at a fairly young age, which made this just so much more true. USE your given time and LIVE as much as possible! Take joy in as many experiences as possible – even if it is a seemingly negative experience.

What inspires you?

Intelligent conversations, great music, my daughter’s energy, family time, and compassion in action. Simoné says her definition of compassion in action is: People like the rest of us with full-time jobs, dedicating every little spare time to helping women/children/families in need or distress; friends involved with finding forever homes for abandoned pets; the regular guy in the street helping a child stand up after falling from the curb.

How do you envision the UFS of the future — especially with regard to women's issues? 

When looking at the simply amazing female leadership emerging at the UFS – academic as well as administrative — I see hope and growth. Just page through the latest issue of Dumela or browse our UFS website: These are strong women; not afraid of embracing who they are and with a need to rise up. I am part of an all-girls team at the South Campus (coincidentally!) and we support each other in every possible way. Whether I know them as Prof, Doc, Ma’am, Mom, Sister, Vriendin – they are all Wonder Women to me.

Tell us something no-one (or only a few people) know about you?

I am in love with (a very broad scope of) music, from Beethoven on full volume to some serious rock. Yes, I sing along to my heart’s content. I am also from Scottish decent and admire my cousins in full costume (kilt and all!).

What does ‘success’ mean to you?

My definition of success has certainly taken a 180-degree turn. When I was still a young student, I longed for academic success and to pursue my PhD studies as soon as possible. Now I am a mom and wife — first and foremost — and still working on my master’s degree. At the end of a fruitful day at the office, a glass of wine with my husband, and hugs, kisses, and laughs from my children, I’d say I had a most successful day.

What ‘words of wisdom’ do you always fall back on? 

I learnt this early on, but had it confirmed in JRR Tolkien’s The Fellowship of the Ring: There is always HOPE.

Lastly, my mom taught me this gem: ‘A little kindness goes a long way.’

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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