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22 August 2019 | Story Eugene Seegers
Simonè Nel (Read More)
“When looking at the simply amazing female leadership emerging at the UFS — academic as well as administrative — I see hope and growth,” says Simoné Nel, a member of the management team on the South Campus.

Simoné Nel heads up the Support Services division on the UFS South Campus. Despite challenges during her youth, she learnt the power of strong examples to look up to, and still lives by the mantra she learnt in primary school from her Drum Majorettes coach. She believes that inspiration can come from mundane sources, day-to-day conversations, or even her children; she is the mother of a 10-year-old son and a 7-year-old daughter. In fact, her best example of teamwork comes from her experiences as mother: “Just watch what happens when a mother is calling frantically for her child if he slips from her grip; EVERYONE helps to find him!”

Tell us about your childhood: What are some of the lessons you learned early on? 

Growing up in the Western Cape, I had a primary school teacher and coach who taught me the value of the saying: “It is not the hours you put in, but what you put into the hours.” I still live by this; trying to make the most of every hour. Both of my parents passed away at a fairly young age, which made this just so much more true. USE your given time and LIVE as much as possible! Take joy in as many experiences as possible – even if it is a seemingly negative experience.

What inspires you?

Intelligent conversations, great music, my daughter’s energy, family time, and compassion in action. Simoné says her definition of compassion in action is: People like the rest of us with full-time jobs, dedicating every little spare time to helping women/children/families in need or distress; friends involved with finding forever homes for abandoned pets; the regular guy in the street helping a child stand up after falling from the curb.

How do you envision the UFS of the future — especially with regard to women's issues? 

When looking at the simply amazing female leadership emerging at the UFS – academic as well as administrative — I see hope and growth. Just page through the latest issue of Dumela or browse our UFS website: These are strong women; not afraid of embracing who they are and with a need to rise up. I am part of an all-girls team at the South Campus (coincidentally!) and we support each other in every possible way. Whether I know them as Prof, Doc, Ma’am, Mom, Sister, Vriendin – they are all Wonder Women to me.

Tell us something no-one (or only a few people) know about you?

I am in love with (a very broad scope of) music, from Beethoven on full volume to some serious rock. Yes, I sing along to my heart’s content. I am also from Scottish decent and admire my cousins in full costume (kilt and all!).

What does ‘success’ mean to you?

My definition of success has certainly taken a 180-degree turn. When I was still a young student, I longed for academic success and to pursue my PhD studies as soon as possible. Now I am a mom and wife — first and foremost — and still working on my master’s degree. At the end of a fruitful day at the office, a glass of wine with my husband, and hugs, kisses, and laughs from my children, I’d say I had a most successful day.

What ‘words of wisdom’ do you always fall back on? 

I learnt this early on, but had it confirmed in JRR Tolkien’s The Fellowship of the Ring: There is always HOPE.

Lastly, my mom taught me this gem: ‘A little kindness goes a long way.’

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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