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22 August 2019 | Story Zama Feni | Photo Charl Devenish
Innocentia working in the lab
UFS academic, Innocensia Mangoato, doing her work in the laboratory.


Born as the only girl among boys in the Tanzanian capital city of Dar es Salaam in 1992, the University of the Free State (UFS) academic Innocensia Mangoato says she feels inspired by women who strive to break the barricades of patriarchy.

“I am inspired by resilient women who are able to overcome everyday challenges, even in a world that treats men as superiors,” she says.

At the tender age of 27, Mangoato has achieved more than many of her peers. Last year, she won a Women in Science Award (WISA) for her research on the use of cannabis in cancer treatment.  She is now a Doctor of Philosophy (PhD) candidate in Pharmacology and also a researcher and lecturer in the Department of Pharmacology – a job she started in May this year.

Early years

Mangoate’s dad was in exile at the ANC base camp outside Morogoro in Tanzania and met her Tanzanian mother during his stay there; she returned with her parents to South Africa in 1994, as political organisations were already unbanned at that time.

One of the factors that Mangoate attributes her academic success to, is her parents. “Both my parents valued education, and I believe this greatly contributed to my development. Coming from a rural upbringing, one of the lessons I learned is that perseverance and hard work always pay off.”

On her navigation of life – trying to determine what exactly could mould her to become what she wanted to be, Mangoate hailed her father as her pillar of strength. “When the going gets tough, my father has always been there to remind me to “keep on keeping on, no matter how hard it may be, because there’s always victory on the other side.”

Academic success

Mangoate obtained her master’s in Pharmacology at the UFS June 2019 graduation ceremony, one month before South Africa celebrates Women’s Month. She brands herself as “a representative of all women in science” and is enjoying empowering young scientists through lecturing and research at the university.

Asked about what nobody else knows about her, Mangoate hesitated for a moment and then beamed, “I am an academic at heart.” There is no doubt about this, as her academic achievements really attest to that.

On how she envisions the UFS in future, especially with regard to women’s issues, she boldly states: “More women will be running departmental affairs, working towards progressive change within the UFS for both the academics and other programmes.”

She interprets success as something that is measured by happiness, being able to help other people reach their goals, and the ability to achieve all one wishes for, while making sure that it’s both impactful and beneficial to others.

Mangoate’s advice to other would-be academic achievers is that they should be focused and determined when it comes to achieving their goals, working diligently in everything they do, “irrespective of whether you like it or not”.

“Being the only girl among boys has taught me to always strive to be better than myself and not to compete with anyone,” says Mangoate.

“Just show up and give it your all.”

News Archive

Link between champagne bubbles and the UFS?
2012-11-16

Prof. Lodewyk Kock with an example of a front page of the publication FEMS Yeast Research, as adapted by F. Belliard, FEMS Central Office.
Photo: Leatitia Pienaar
15 November 2012

What is the link between the bubbles in champagne and breakthrough research being done at the Mayo Clinic in America? Nano research being done at our university.

Prof. Lodewyk Kock of Biotechnology says a human being consists of millions of minute cells that are invisible to the eye. The nano technology team at the UFS have developed a technique that allows researchers to look into such a cell, as well as other microorganisms. In this way, they can get an idea of what the cell’s “insides” look like.

The UFS team – consisting of Profs. Kock, Hendrik Swart (Physics), Pieter van Wyk (Centre for Microscopy), as well as Dr Chantel Swart (Biotechnology), Dr Carlien Pohl (Biotechnology) and Liza Coetsee (Physics) – were amazed to see that the inside of cells consist of a maze of small tunnels or blisters. Each tunnel is about 100 and more nanometres in diameter – about one ten thousandth of a millimetre – that weaves through the cells in a maze.

It was also found that these tunnels are the “lungs” of the cells. Academics doing research on yeast have had to sit up and take notice of the research being done at the UFS – to the extent that these “lungs” will appear on the front page of the highly acclaimed FEMS Yeast Research for all of 2013.

The Mayo Clinic, in particular, now wants to work with the UFS to study cancer cells in more detail in order to fight this disease, says Prof. Kock. The National Cancer Institute of America has also shown interest. This new nano technology for biology can assist in the study and development of nano medicine that can be used in the treatment of cancer and other life threatening diseases. Nano medicine uses nano metal participles that are up to one billionth of a metre in size.

Prof. Kock says laboratory tests indicate that nano medicine can improve the efficacy of anti-cancer medicine, which makes the treatment less toxic. “According to the Mayo Clinic team, nano particles are considered as a gold cartridge which is being fired directly at a cancer tumour. This is compared to fine shot that spreads through the body and also attacks healthy cells.”

“This accuracy implies that the chemotherapy dose can be lowered with fewer side effects. The Mayo Clinic found that one-tenth of the normal dosage is more effective against pancreas cancer in this way than the full dosage with a linkage to nano particles. According to the clinic, this nano medicine could also delay the spread of cancer,” says Prof. Kock.

The nano particles are used as messengers that convey anti-cancer treatment to cancer cells, where it then selectively kills the cancer cells. The transport and transfer of these medicines with regard to gold nano particles can be traced with the UFS’s nano technology to collect more information, especially where it works on the cell.

“With the new nano technology of the UFS, it is possible to do nano surgery on the cells by slicing the cells in nanometre thin slices while the working of the nano medicine is studied. In this way, it can be established if the nano medicine penetrates the cells or if it is only associated with the tiny tunnels,” says Prof. Kock.

And in champagne the small “lungs” are responsible for the bubbles. The same applies to beer and with this discovery a whole new reach field opens for scientists.

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