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22 August 2019 | Story Zama Feni | Photo Charl Devenish
Innocentia working in the lab
UFS academic, Innocensia Mangoato, doing her work in the laboratory.


Born as the only girl among boys in the Tanzanian capital city of Dar es Salaam in 1992, the University of the Free State (UFS) academic Innocensia Mangoato says she feels inspired by women who strive to break the barricades of patriarchy.

“I am inspired by resilient women who are able to overcome everyday challenges, even in a world that treats men as superiors,” she says.

At the tender age of 27, Mangoato has achieved more than many of her peers. Last year, she won a Women in Science Award (WISA) for her research on the use of cannabis in cancer treatment.  She is now a Doctor of Philosophy (PhD) candidate in Pharmacology and also a researcher and lecturer in the Department of Pharmacology – a job she started in May this year.

Early years

Mangoate’s dad was in exile at the ANC base camp outside Morogoro in Tanzania and met her Tanzanian mother during his stay there; she returned with her parents to South Africa in 1994, as political organisations were already unbanned at that time.

One of the factors that Mangoate attributes her academic success to, is her parents. “Both my parents valued education, and I believe this greatly contributed to my development. Coming from a rural upbringing, one of the lessons I learned is that perseverance and hard work always pay off.”

On her navigation of life – trying to determine what exactly could mould her to become what she wanted to be, Mangoate hailed her father as her pillar of strength. “When the going gets tough, my father has always been there to remind me to “keep on keeping on, no matter how hard it may be, because there’s always victory on the other side.”

Academic success

Mangoate obtained her master’s in Pharmacology at the UFS June 2019 graduation ceremony, one month before South Africa celebrates Women’s Month. She brands herself as “a representative of all women in science” and is enjoying empowering young scientists through lecturing and research at the university.

Asked about what nobody else knows about her, Mangoate hesitated for a moment and then beamed, “I am an academic at heart.” There is no doubt about this, as her academic achievements really attest to that.

On how she envisions the UFS in future, especially with regard to women’s issues, she boldly states: “More women will be running departmental affairs, working towards progressive change within the UFS for both the academics and other programmes.”

She interprets success as something that is measured by happiness, being able to help other people reach their goals, and the ability to achieve all one wishes for, while making sure that it’s both impactful and beneficial to others.

Mangoate’s advice to other would-be academic achievers is that they should be focused and determined when it comes to achieving their goals, working diligently in everything they do, “irrespective of whether you like it or not”.

“Being the only girl among boys has taught me to always strive to be better than myself and not to compete with anyone,” says Mangoate.

“Just show up and give it your all.”

News Archive

Collaboration between UFS and Mayo Clinic to revolutionise cancer treatment
2014-06-27



Attending the lecture were, from the left: Dr Chantel Swart, Prof Lodewyk Kock, Prof Debabrata Mukhopadhyay, Prof James du Preez; back: Prof Pieter van Wyk.
Dr Swart, Profs Kock and Du Preez are from the Department of Microbial, Biochemical and Food Biotechnology. Prof Mukhopadhyay is from the Mayo Clinic (US) and Prof Van Wyk is from the Centre for Microscopy at the UFS.
Photo: Supplied
The UFS made a discovery that may have enormous implications for the treatment of diseases in humans.

Since the discovery, the UFS joined forces with the Mayo Clinic in Rochester, US, in the fight against cancer.

In this collective effort, UFS researchers would be able to assist the Mayo team to:
• see how treatment in cancer patients is progressing,
• target treatments more effectively,
• reduce dosages in order to make treatment gentler on the patient,
• track the effectiveness of the chemotherapy drugs used, and
• gain an accurate view of how the cancer is being eliminated.

Prof Lodewyk Kock, Outstanding Professor at the Department of Microbial, Biochemical and Food Biotechnology, and his team incidentally created a technique to use argon gas particles for the first time on biological material to slice open cells to look inside.

The team that supported Prof Kock includes Dr Chantel Swart, Khumisho Dithebe (PhD student), Prof Hendrik Swart (Department of Physics) and Prof Pieter van Wyk (Centre for Microscopy).

Prof Debabrata Mukhopadhyay from the Mayo Clinic in Rochester, US, got to hear about this breakthrough at the UFS and a collaboration between the two institutions was established.

During a visit to the Bloemfontein Campus, Prof Mukhopadhyay explained novel techniques that make use of gold nanoparticles. These particles attach to chemotherapeutic drugs to selectively target cancer cells – dramatically decreasing the side effects to normal human cells.

For these new drugs (coupled to gold nanoparticles) to be accepted into clinical practice, visual and chemical proof is needed, though. This is where the technique developed by the UFS will play a vital role.

With the technique to look inside cells, the composition, location and metabolism of these drugs can be determined. This will aid in a proof of concept for the application of the nano-drugs. Furthermore, it will enable approval for use of these drugs in clinical trials and eventually could revolutionise cancer treatment as a whole.

For video lectures on the technique used, as well as its findings, follow these links:

1. http://vimeo.com/63643628 (Comic version for school kids)

2. http://vimeo.com/61521401 (Detailed version for fellow scientists)

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