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13 December 2019 | Story Valentino Ndaba | Photo Johan Roux
Dr Thandi
After nearly seven years Dr Lewin finally graduates with a PhD.

Dr Thandi Lewin has spent the past six-and-a-half years of her life on her PhD.  It was only in the final year of the process that the thesis came together. “I had a few chapters and had done literature reviews and some theoretical work, as well as a little initial analysis, but none of it actually added up to a coherent thesis. The moment when I realised that I actually did have a thesis was a great feeling and a huge relief because it was only then that the end was in sight,” she said. 

On Wednesday 11 December 2019 her diligence culminated in a graduation ceremony at which she obtained her PhD in Higher Education Studies in the Faculty of Education at the University of the Free State (UFS). Dr Lewin formed a part of the pioneering cohort of the South African Research Chairs Initiative (SARChI) Chair in Higher Education and Human Development Research Programme, under the leadership of Professor Melanie Walker

Through the twists and turns

Working on her thesis on Early career women academics: A case study of working lives in a gendered institution, Dr Lewin struggled with time constraints. “I could not work on it every night or every early morning like some people do. My job was demanding, so I worked most nights and often went to bed quite late. Hence, I failed to focus on it during the week,” she explained.

When she began her PhD her youngest child was one year old. In addition to her job becoming more and more challenging over the years, Dr Lewin also had to maintain a morning and evening routine in order to make the most of the limited time she and her family had together. Yet after all was said and done, her research still beckoned.

Reaching the stage of walking across the stage

Given the rigorous process of completing a PhD, one of the major motivators was her supervisor. “Prof Walker was loyal and never gave up on me. She was also pragmatic and understanding. The commitment from a supervisor who is considerate of your personal circumstances, but is also as dedicated to your research project as you are, is quite something to find.”

For much of the past three years of her doctorate, Dr Lewin’s father was ill. He eventually succumbed to his illness in January 2019. The graduate struggled with managing her emotions as she felt guilty about not spending enough time with him due to work and research. “Being a mum and a daughter meant that if I wasn’t at work or working on my PhD I was with my kids or with my dad. But I must also acknowledge that my partner, nanny, and part-time housekeeper provided critical support which I couldn’t have done without.”

On gender and organisational cultures

The Chief Director for Institutional Governance and Management support in the university education branch of the Department of Higher Education and Training found the experience garnered in the system-level of higher learning enormously helpful in her research process.   “I have really enjoyed working in an area that interests me, and engaging with a topic that is policy-relevant,” she said.

Content
Melanie Walker (right) reading the PhD appraisal for Dr Thandi Lewin at the Graduation Ceremony.
(Photo: Johan Roux)


Cultivating culture change

Enabling women to rise through the ranks would require more effort to improve gender equity. “Organisations and universities can never really achieve gender equity without fundamentally changing their structures and cultures, which are deeply gendered. This also cannot happen without social change, which needs to take place in broader society and not only within organisations,” said Dr Lewin.

What this means for society and organisations is a shift from focusing solely on individual women. According to Dr Lewin: “Universities, in addition to their inclination towards slow change, are also experienced by many as exclusionary – not just by women, but by people of colour and those from working-class backgrounds, and others who have been traditionally marginalised in higher education. This is a critical issue for South African higher education – it is going to take a lot of time and focused commitment to change the cultures of universities to be more inclusive.”

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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