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13 December 2019 | Story Valentino Ndaba | Photo Johan Roux
Dr Thandi
After nearly seven years Dr Lewin finally graduates with a PhD.

Dr Thandi Lewin has spent the past six-and-a-half years of her life on her PhD.  It was only in the final year of the process that the thesis came together. “I had a few chapters and had done literature reviews and some theoretical work, as well as a little initial analysis, but none of it actually added up to a coherent thesis. The moment when I realised that I actually did have a thesis was a great feeling and a huge relief because it was only then that the end was in sight,” she said. 

On Wednesday 11 December 2019 her diligence culminated in a graduation ceremony at which she obtained her PhD in Higher Education Studies in the Faculty of Education at the University of the Free State (UFS). Dr Lewin formed a part of the pioneering cohort of the South African Research Chairs Initiative (SARChI) Chair in Higher Education and Human Development Research Programme, under the leadership of Professor Melanie Walker

Through the twists and turns

Working on her thesis on Early career women academics: A case study of working lives in a gendered institution, Dr Lewin struggled with time constraints. “I could not work on it every night or every early morning like some people do. My job was demanding, so I worked most nights and often went to bed quite late. Hence, I failed to focus on it during the week,” she explained.

When she began her PhD her youngest child was one year old. In addition to her job becoming more and more challenging over the years, Dr Lewin also had to maintain a morning and evening routine in order to make the most of the limited time she and her family had together. Yet after all was said and done, her research still beckoned.

Reaching the stage of walking across the stage

Given the rigorous process of completing a PhD, one of the major motivators was her supervisor. “Prof Walker was loyal and never gave up on me. She was also pragmatic and understanding. The commitment from a supervisor who is considerate of your personal circumstances, but is also as dedicated to your research project as you are, is quite something to find.”

For much of the past three years of her doctorate, Dr Lewin’s father was ill. He eventually succumbed to his illness in January 2019. The graduate struggled with managing her emotions as she felt guilty about not spending enough time with him due to work and research. “Being a mum and a daughter meant that if I wasn’t at work or working on my PhD I was with my kids or with my dad. But I must also acknowledge that my partner, nanny, and part-time housekeeper provided critical support which I couldn’t have done without.”

On gender and organisational cultures

The Chief Director for Institutional Governance and Management support in the university education branch of the Department of Higher Education and Training found the experience garnered in the system-level of higher learning enormously helpful in her research process.   “I have really enjoyed working in an area that interests me, and engaging with a topic that is policy-relevant,” she said.

Content
Melanie Walker (right) reading the PhD appraisal for Dr Thandi Lewin at the Graduation Ceremony.
(Photo: Johan Roux)


Cultivating culture change

Enabling women to rise through the ranks would require more effort to improve gender equity. “Organisations and universities can never really achieve gender equity without fundamentally changing their structures and cultures, which are deeply gendered. This also cannot happen without social change, which needs to take place in broader society and not only within organisations,” said Dr Lewin.

What this means for society and organisations is a shift from focusing solely on individual women. According to Dr Lewin: “Universities, in addition to their inclination towards slow change, are also experienced by many as exclusionary – not just by women, but by people of colour and those from working-class backgrounds, and others who have been traditionally marginalised in higher education. This is a critical issue for South African higher education – it is going to take a lot of time and focused commitment to change the cultures of universities to be more inclusive.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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