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01 January 2020 | Story Eugene Seegers | Photo Kaleidoscope Studios | Sonia Small
Kaleidoscope - Dr Maria Madiope - New South Campus Principal
Dr Maria Madiope took over the reins of the UFS South Campus at the beginning of January 2020.

The Council of the University of the Free State (UFS) approved the appointment of Dr Maria ‘Marinkie’ Madiope as Principal of the South Campus for Open Distance Learning (ODL) during a meeting held on 20 September 2019. Dr Madiope took over the reins of the UFS South Campus at the beginning of January 2020.

Educator at heart

Educating and empowering others are key aspects of Dr Madiope's life. She has served as the Director for University Teaching and Learning at Unisa since 2015 and takes her role incredibly seriously, achieving a transformative curriculum at the colleges under her care since her appointment.

Dr Madiope holds a PhD in Education from Unisa, with a specialisation in Didactics; her next two degrees where completed at the then RAU, which is today known as the University of Johannesburg: a BEd in 1999, followed by an MEd in 2001, both specialising in Computer-based Instruction. She previously obtained her BA Ed in 1985 and a BEd in 1988 from the University of the North. Her initial training as a teacher was from the Hebron College of Education from 1980-81.

Dr Madiope is also the editor of the only journal in ODL, Progressio, since 2016. Her expertise in E-learning is another of her strong points. Together with her team, Dr Madiope designed and developed the first online course in Curriculum Transformation, which is being piloted at Unisa. Her work has been rewarded with awards such as the Unisa Gender Activism: Advocacy and Promotion of Women’s Rights 2013, Unisa Woman of the Year 2013, and Unisa Best Performer 2013.

Dr Madiope brings with her a wealth of experience to UFS and her vision is to increase access to a wider base of learners with potentially having more African learners enrolled. The first point of call would be to have more learners coming from Lesotho and then the rest of the SADEC region, having the UFS become a leading distance-learning university. One of the key projects that Dr Madiope wishes to tackle is early childhood development. “I believe in educating educators to ensure that they are best equipped to provide the latest and relevant Early childhood and development practices that are on par with the rest of the world,” she says.

Community leader

In addition to being an experienced educator and administrator, Dr Madiope is instrumental in community projects that lie close to her heart. Whether it is large-scale advocacy for women’s rights or her personal involvement in the supply of sanitary towels for schoolgirls as part of a programme to empower the girl child through exposing them to options, it is humbling to watch her compassion in action.

She further intends to strengthen the relationship of the university with TVET Colleges and community colleges by providing mutually beneficial programmes that will up-skill those colleagues by giving them an opportunity to work with experienced UFS staff members. She says, “Reaching out to colleagues in TVET and Community colleges will offer them the opportunity to advance their lecturing and learning programmes, which will only lead to benefiting their learners and South Africa as a whole.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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