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08 July 2019 | Story Xolisa Mnukwa | Photo Charl Devenish
Thought-Leader Series 2019
Executive Director: Centre for Politics and Research and political commentator, Prince Mashele, one of the key experts at the UFS Thought-Leader series, advises the youth in South Africa on acquiring multidisciplinary skills in order to survive in the future world of work.

The University of the Free State (UFS), in collaboration with Vrye Weekblad, presented the second consecutive Thought-Leader series on the Bloemfontein Campus on 4 July 2019, with topics focusing on economic growth and entrepreneurship for an emergent South African economy and environment. The series formed part of the literature festival of the Vrystaat Arts Festival, presented on the campus from 1 to 7 July 2019.

Rector and Vice-Chancellor of the UFS, Prof Francis Petersen, opened the discussions with the words, “We need to project ourselves as thought-leaders,” clarifying that the UFS itself is responsible for contributing to local and national public discourse by assembling industry experts to deliberate on imperative topics that affect students, the broader community, and the country in one way or another.  

Editor of the Vrye Weekblad, political analyst, and master of ceremonies for the morning, Dr Max du Preez, introduced the panellists for the first discussion, themed How can we fix the South African economy and create jobs.

According to Prof Philippe Burger, Vice-Dean (Strategic Projects): UFS Faculty of Economic and Management Sciences, South Africa has the highest level of economic inequality in the world. He further explained that the long-term solution to growing the country’s economy is to improve the quality of education, which will result in a higher growth rate for the country.

Chief Economist at Investec, Ms Annabel Bishop, went on to explain that, “South Africa has a worrying de-industrialisation trend, which contributes to the decreased opportunity for decent job creation, essentially contributing to our struggling economy.” This was echoed by Executive Director: Centre for Politics and Research and political commentator, Mr Prince Mashele, who spoke on employing the unemployed. He suggested that South Africa’s youth be trained and equipped with skills so that SA gravitate more towards producing an industrial class in order to build its economy.

Director and Chief Economist of the Efficient Group, Mr Dawie Roodt, concluded the first discussion by highlighting that South Africa needs a GDP growth rate of 2,5% to at least maintain the country’s current unemployment rate and prevent it from getting worse. 

The second panel discussed the establishment of a pro-youth entrepreneurship country, where the Head: Department of Business Management (UFS), Prof Brownhilder Neheh, spoke about bridging the intention-behaviour gap, and further exposing the youth to practical opportunities and teaching them the importance of group mentality as entrepreneurs. Chief Executive Officer: Harambee Youth Employment Accelerator, Ms Maryana Iskander, suggested that foreign direct investment can improve youth employment.

The final panellist to speak during the last half of the discussion, Senior Banker and Transactor: Acquisition and Leveraged Finance Division at Rand Merchant Bank – Corporate Investment Bank, Mr David Abbey, advised on tomorrow’s world of work by saying, “The focus of the workplace should always be on the people, and entrepreneurs should understand the importance of multidisciplinary skills, and emotional and social intelligence, as the future world of work requires a trusted society.”

 


UFS Thought-Leader Series
Programme: 

 

UFS Thought-Leader Series
Panel discussions:

 
 UFS Thought-Leader Series Programme  
 



News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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