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12 July 2019 | Story Ruan Bruwer | Photo Tania Allen
Tanya von Berg
Tanya von Berg has represented the UFS netball team with distinction over seven years, winning three Varsity Netball titles and one USSA crown.

Although she did not quite reach her final goal in a Kovsie netball dress, being honoured one last time brought much peace to Tanya von Berg.

She was named in the Dream Team at the conclusion of the University Sport South Africa (USSA) tournament in Johannesburg and was thus recognised as the best centre at the competition.

According to the stalwart who played in her seventh year for the University of the Free State, her goal was to make this team and lift the trophy. The team didn’t succeed in the latter, losing to the North-West University in the semi-final.

Heading abroad
“Knowing that it would be the last time I would be playing for the team, I set myself these two goals. Although we were not able to claim the title, at least making the Dream Team helped to make me feel that I finished on a high, giving my all one last time,” she said.

Von Berg, who is doing her honours in Education this year, received a teaching post in Qatar, where she will start in August.

Remarkably this versatile player, who could play any one of four positions, only missed two matches in the two student competitions since making her debut as a first-year student in 2013. This was due to national commitments in 2016 (playing for South Africa A) and her honeymoon last year.

Standout moments
“Being named for the Protea training squad in 2016 and being selected for the national Fast5 team later that year, was the two outstanding moments of my career.”
“What I remember about my first year, was how huge it was to play with the seniors. The one player who served as my biggest inspiration, was Isélma Parkin. She didn’t receive the recognition she deserved. I learned from her to continue to work hard and to never give up.”


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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