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24 July 2019 | Story Valentino Ndaba | Photo Valentino Ndaba
Dr Lazlo Passemiers
Dr Lazlo Passemiers spent six years conducting research across three continents.

A keen interest in unravelling transnational histories of 20th-century Southern Africa led Postdoctoral Research Fellow Dr Lazlo Passemiers to spend six years conducting extensive research across three continents. Dr Passemiers sifted through archives in Africa, Europe, and the US in order to convert his PhD thesis into a monograph.

It was on 17 July 2019 that the fruits of Passemiers’ labour were officially launched by the International Studies Group at the University of the Free State’s Bloemfontein Campus. His book, Decolonisation and Regional Geopolitics: South Africa and the ‘Congo Crisis’, 1960-1965, offers an important shift in the historiography of the Congo Crisis. It creatively centres African involvement in the debate by examining this event from a regional geopolitical angle. 

Going back in time 

By providing a three-fold perspective that examines decolonisation, apartheid diplomacy, and Southern African nationalist movements, the book offers a rounded picture of South African involvement in the Congo Crisis.

Dr Passemiers’ fascination with the transnational dynamics of Southern Africa’s history has rippled into two new research projects that respectively explore “the connection between decolonisation and white flight in the region as well as the transnational support networks of liberation movements”.

Finding the missing pieces of the puzzle

Prof Christopher Saunders, Emeritus Professor at the University of Cape Town, commended Dr Passemiers’ historiographical contribution: “He has identified a major gap in the literature and he has filled it admirably by looking across the spectrum.” As Prof Saunders noted, “what has been missing in the literature is the African angle.” 

Literature’s role in transformation

The process of undoing the profound impact of colonialism on society is long and difficult and important in this process is a clear understanding of history, which Dr Passemiers’ book enhances.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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