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Fulbright scholar wants to improve lives of HIV/Aids patients

25 June 2019 | Story Leonie Bolleurs | Photo Barend Nagel

Marnus du Plooy will receive his master’s degree at the University of the Free State’s Winter Graduation Ceremony.

After completing his BSc degree in Microbiology, he discovered a passion for this field of research and enrolled for postgraduate studies in the Department of Microbial, Biochemical and Food Biotechnology at the UFS.

During his master’s, Du Plooy focused on the pathogenic yeasts, Cryptococcus neoformans and a related species, C. deneoformans.

Passion for science instilled at a young age

His passion for this field comes from a young age. “Both my parents were Science teachers and they instilled a love for Science in me. At school, I enjoyed the Science subjects the most and usually obtained my highest marks in these,” Du Plooy said.

The pathogenic yeasts studied by Du Plooy, Cryptococcus neoformans and the sister species, C. deneoformans, often cause meningitis in immunocompromised individuals, such as in people living with HIV/Aids.

He pointed out: “Infection caused by these yeasts is right on the heels of TB as the second largest killer of HIV-positive patients in sub-Saharan Africa. The focus of my master’s project was to investigate new ways in which genes can be ‘switched off’ in these yeasts in order to study the role of the genes in virulence. Doing so could help to identify new drug targets for the treatment of this form of meningitis in subsequent studies.”

Expanding his international footprint

Although Du Plooy received his master’s degree from the UFS, he grabbed the opportunity to study abroad with both hands. He applied for and received a Fulbright scholarship from the Fulbright Foreign Student Programme, giving him the opportunity to study in the US.

“I did not expect to get very far with the application, as very few candidates are selected each year. I was very lucky to receive a Fulbright scholarship and an admission offer from Duke University for PhD studies in Microbiology,” said Du Plooy.

He hopes to continue with research on Cryptococcus and to contribute to improving the lives of HIV/Aids patients. “I have always been interested in pharmaceutical and medical research and noticed a need for better cryptococcal treatments, especially in sub-Saharan Africa. Cryptococcal meningitis is a neglected disease which claims more than 600 000 lives worldwide every year. The current treatment options are several decades old, with some only available in well-resourced areas.”

Du Plooy will depart for the US in August. “The duration of the degree is four to five years, where-after I will return to South Africa to apply what I have learned at home.”

News Archive

International Year of Crystallography attracts science experts from across the globe

2014-10-13

Video: Discover what Chrystallopgraphy can do for you
Video: Celebrating Crystallography: An Animated Adventure

Summit programme

The third world summit in the International Year of Crystallography (in Africa) will be hosted by the UFS Department of Chemistry here on the Bloemfontein Campus. Prof André Roodt, Head of the Department of Chemistry, was elected as the President of the European Crystallographic Association in 2012. Earlier this year he unveiled the Max von Laue 'Plaque' in Posnan, Poland.

The Pan-African Meeting of the International Year of Crystallography consists of a congress and summit. The details are as follows:

Congress
12–15 October 2014
CR Swart Senate Hall, UFS Bloemfontein Campus

Summit
15–17 October 2014
CR Swart Senate Hall, UFS Bloemfontein Campus
Summit opening: Wednesday 15 October 2014 at 14:00 in the CR Swart Senate Hall

This event will be opened and attended by:
•   the UFS Rector and Vice-Rector – Profs Jonathan Jansen and Corli Witthuhn;
•   the acting Director-General of the Department of Science and Technology – Dr Thomas Auf der Heyde;
•   the acting CEO of the National Research Foundation – Dr Gansen Pillay;
•   the UNESCO Vice-Director for Science Extension – Dr Jean-Paul Ngome-Abiaga (Paris, France);
•   the representative of the Executive Committee for the International Union of Crystallography (IUCr) – Prof Santiago Garcia-Granda (Oviedo: Spain);
•   the marketing director of the IUCr – Prof Michele Zema (Pavia, Italy);
•   the President of the European Crystallographic Association (ECA) – Prof André Roodt, who will officially open the summit on Wednesday 15 October 2014 from 14:00–15:30.

Presenters from across Africa and Europe will deliver papers at this event which will be attended by more than 100 delegates from twenty-plus countries, including Spain, France, Italy, Croatia, Germany, Russia and India.

Numerous crystallographic research areas will be covered. This includes:
•   powder diffraction,
•   small molecule crystallography,
•   biological crystallography,
•   industrial crystallography,
•   surface crystallography,
as well as techniques such as
•   electron microscopy and
•   synchrotron work.

“At this event we hope to establish an African Crystallographic Association,” said Prof Roodt.

The United Nations declared 2014 as the International Year of Crystallography. It was recently officially opened at the UNESCO headquarters in Paris, France, by the Secretary General of the UN, Ban Ki-moon.

The International Year of Crystallography celebrates the centennial of the work of Max von Laue and the father and son, William Henry and William Laurence Bragg. More generally, it celebrates what crystallography can do for humanity – which proves to be a significant amount.

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