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21 June 2019 | Story Ruan Bruwer | Photo Ruan Bruwer
Braam van Wyk
Braam van Wyk, hockey high-performance manager at the University of the Free State, should gain valuable experience with the Ghana men’s hockey team.

Braam van Wyk, hockey high-performance manager at the University of the Free State (UFS), wants to plough back whatever he can at international level.

Van Wyk has been appointed as assistant coach of the Ghana men’s hockey team. It is only a part-time appointment, as they don’t play that many matches in a year. Ghana is ranked 35th in the world.  

He will assist the team in the run-up to the Africa Cup in August 2019, where they hope to perform well enough to get an opportunity to play in the Road to Tokyo qualifier for next year’s Olympic Games. 

Van Wyk currently coaches the Ghana players who are based in South Africa. 

“I see this as an opportunity to develop the players, but also for me as a coach to grow and to coach at international level. I am excited to try and add value. The plan is to implement it here at the UFS,” Van Wyk said.

He is also the head coach of the UFS men’s team since 2016, as well as the astro manager.

Learned a lot from coach dad

According to Van Wyk (32), who studied environmental management, he already started coaching in his first year of studies while he was still playing. He represented the UFS from 2006 to 2009. 

“Between 2010 and 2015, my focus shifted to umpiring and I officiated in 19 internationals of which five involved the Protea men’s team.” 

His father, also Braam, is never too far away for guidance. Braam Sr is an astute coach who stood at the helm of many teams over the years, including the Kovsie men and women. He also coached his son while he was playing for the UFS.

“While I was playing, I used to ask him a lot of questions. I learned so much from him and still approach him for advice. He has so much experience and has achieved so much.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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