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22 March 2019 | Story Rulanzen Martin | Photo Stephen Collett
Prof Johann Rossouw Inaugural lecture
Prof Heidi Hudson, Dean of the Faculty of the Humanities; Prof Fani de Beer, Prof Rossouw’s mentor; Prof Johann Rossouw; and Dr Engela van Staden, Vice-Rector: Academic.

For Prof Johann Rossouw from the Department of Philosophy, the Naval Hill Planetarium – a digital planetarium on a hill in the centre of a modern city, was the perfect place to deliver his inaugural lecture titled, The soul of the academy.

The message of his inaugural lecture was on “the form adopted by the contemporary university, which is so focused on the quantitative that the qualitative is neglected. The focus on training is so strong that the university no longer pays attention to the education of students”.

Prof Rossouw referred to the soul of the academy as the highest in humanity, especially the part which cannot be counted. He also referred to the words of Blaise Pascal in the 17th century: “The heart has its reasons of which reason knows nothing”.

“Do we understand any of this in the contemporary university? And do we still remember the earliest origins from which the academy originated; that Philosophy is the mother discipline of all other disciplines, and how all contemporary disciplines form part of a bigger, coherent entity?” he asked.

The inaugural lecture took place on 28 February 2019. Prof Rossouw has a C2-rating from the National Research Foundation, and it is thanks to him, among other things, that the Department of Philosophy is the only South African Philosophy department with modernity studies as its main focus.

At the end of 2018, he was promoted to Professor of Philosophy at the University of the Free State (UFS), and currently he serves as acting Head of Department. “Due to Prof Rossouw’s involvement, among other things, research on African philosophy, critical theory, postcolonial thinking, and tradition and modernity is conducted in the department,” Prof Heidi Hudson (Dean: the Humanities) said.

Prof Rossouw started his formal training in Philosophy at the age of 12, and in 1991 he obtained a BA degree majoring in Philosophy and Psychology at the University of Pretoria, with distinction. He obtained his MA degree, a critical study of apartheid on the basis of Michel Foucault’s thinking, at Unisa in 1998. In 2002, he obtained his DEA in Philosophy at the University of Lyon 3 under the leadership of Régis Debray, and in 2013 his PHD on the theological trail in Bernard Stiegler’s thinking at Monsh University (Melbourne), under Michael Janover.

In 2016, he won a prize from the South African Academy for Science and Culture for one of the best Afrikaans humanity articles published in 2015.

 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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