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12 March 2019 | Story Eugene Seegers | Photo Eugene Seegers
Leading women honoured at faculty opening
Rev Martin Laubscher pictured with Thandeka Khulu, Oarabetse Morokane, Lunette Visser, and Trunette Sevenster, who participated in the worship service.

At its recent opening, the Faculty of Theology and Religion conferred the inaugural Letsema Award on Dr Ellen Vuyiswa Blekie, a medical doctor known for her sterling work in her local community in Thaba Nchu, as well as on the various church councils and committees on which she still serves at the age of 87. Dr Gideon van der Watt, director of the “Partners in Mission” unit of the Dutch Reformed Church in the Free State, presented the award to Dr Blekie on behalf of the faculty.

The theme of the morning’s proceedings was: The church and violence against women and children. This theme was not only borne out by the worship service presented by Rev Martin Laubscher, but also by each of his participants. First, a popular song from 1987, My Name is Luka, by Suzanne Vega, was recited in spoken-word form. The song deals with themes of physical and emotional abuse, as well as being kept silent as a victim. Next, the Paulette Kelly poem I Got Flowers Today was recited. The final stanza begins with the words “I got flowers today.../Today was a special day — it was the day of my funeral...”

Dr Carin van Schalkwyk, who has been serving the Philippolis community and congregation since 1993, conducted the liturgy. Her chosen passage was 2 Samuel 13, which recounts the events leading up to King David’s son Amnon raping his half-sister Tamar and the subsequent cover-up by the king and his sons. Dr Van Schalkwyk likened the way David of old handled the situation to the modern church’s failure regarding the protection of women and children, stating these vulnerable ones have been failed miserably.

Dr Van Schalkwyk added: “The root of the problem has not been addressed. It requires a rethinking of both preaching and policy, even of theology. All are created in God’s image; what does that mean?”

Concluding, she said, “We need to hear the lament of those affected, and weep with them. I dream of a day when women do not have to think of how to avoid sexual harassment on a daily basis.”


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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