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28 March 2019 | Story Thabo Kessah | Photo Thabo Kessah
Teboho Mofokeng
Postgraduate Student Council and SRC member, Teboho Mofokeng, says one degree is not enough.

Postgraduate studies play a crucial and critical role in the missions of our universities. They also contribute to the key and central mandate of the university – knowledge production, the dissemination, and application thereof.

The Campus Principal, Dr Martin Mandew, expressed this view during a welcoming function for postgraduate students on the Qwaqwa Campus. “Our Postgraduate School is the gateway that enables entry into higher degrees and qualifications. It is an extremely valuable resource and support reference point which is at the disposal of the students,” he said.

Postgraduate research and national development

Dr Mandew added that postgraduate research plays a very important role in national development, as it develops systematic investigation skills among young graduates for the purpose of making a contribution to what he termed ‘the national system of innovation’. “It also ensures that the country is competitive and enables the generation of knowledge that is responsive to societal needs, among others,” he said.

“Doing postgraduate studies is not easy,” he added. “Challenges that postgraduate students have to contend with, include funding and financial problems; lack of equipment; inadequate library facilities; access to research materials, and many more,” Dr Mandew said.

Support broadens knowledge and skills

In detailing the services offered by the Postgraduate School, the Director, Prof Witness Mudzi, assured students that they would experience an enabling environment to excel in the pursuit of their academic quests. “We will provide additional support to that provided by facilities and departments in the form of workshops, courses, and other presentations, which will equip the students with the requisite skills for successful completion of their postgraduate education.”

“The workshops and courses we offer are aimed at broadening your knowledge of research processes and methods. This would then positively influence throughput, publications, and the quality of research produced,” Prof Mudzi said to a packed venue.

Speaking on behalf of the SRC and the Postgraduate Student Council, Chairperson Teboho Mofokeng said that the event was held at a time when final-year students were asking themselves if it was worth continuing with postgraduate studies. “Do not take the decision to continue with your postgraduate studies lightly,” he said. “We work in a knowledge economy where specialised skills have significant commercial value. This means that in today’s competitive job market, it is often not enough to have only one degree,” said Mofokeng, a beneficiary of the school’s Mentorship Programme and master’s student specialising in Parasitology.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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