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28 March 2019 | Story Thabo Kessah | Photo Thabo Kessah
Teboho Mofokeng
Postgraduate Student Council and SRC member, Teboho Mofokeng, says one degree is not enough.

Postgraduate studies play a crucial and critical role in the missions of our universities. They also contribute to the key and central mandate of the university – knowledge production, the dissemination, and application thereof.

The Campus Principal, Dr Martin Mandew, expressed this view during a welcoming function for postgraduate students on the Qwaqwa Campus. “Our Postgraduate School is the gateway that enables entry into higher degrees and qualifications. It is an extremely valuable resource and support reference point which is at the disposal of the students,” he said.

Postgraduate research and national development

Dr Mandew added that postgraduate research plays a very important role in national development, as it develops systematic investigation skills among young graduates for the purpose of making a contribution to what he termed ‘the national system of innovation’. “It also ensures that the country is competitive and enables the generation of knowledge that is responsive to societal needs, among others,” he said.

“Doing postgraduate studies is not easy,” he added. “Challenges that postgraduate students have to contend with, include funding and financial problems; lack of equipment; inadequate library facilities; access to research materials, and many more,” Dr Mandew said.

Support broadens knowledge and skills

In detailing the services offered by the Postgraduate School, the Director, Prof Witness Mudzi, assured students that they would experience an enabling environment to excel in the pursuit of their academic quests. “We will provide additional support to that provided by facilities and departments in the form of workshops, courses, and other presentations, which will equip the students with the requisite skills for successful completion of their postgraduate education.”

“The workshops and courses we offer are aimed at broadening your knowledge of research processes and methods. This would then positively influence throughput, publications, and the quality of research produced,” Prof Mudzi said to a packed venue.

Speaking on behalf of the SRC and the Postgraduate Student Council, Chairperson Teboho Mofokeng said that the event was held at a time when final-year students were asking themselves if it was worth continuing with postgraduate studies. “Do not take the decision to continue with your postgraduate studies lightly,” he said. “We work in a knowledge economy where specialised skills have significant commercial value. This means that in today’s competitive job market, it is often not enough to have only one degree,” said Mofokeng, a beneficiary of the school’s Mentorship Programme and master’s student specialising in Parasitology.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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