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13 May 2019 | Story Zama Feni | Photo Charl Devenish
Dr Quinton Meyer and Marlena Visagie
National Control Laboratory Deputy Director, Dr Quinton Meyer (right), and Marlena Visagie, Quality Assurance Manager, at the laboratory within their facilities at the University of the Free State.

The University of the Free State-based National Control Laboratory for Biological Products (NCL) has maintained its esteemed status as a pharmaceutical testing laboratory after the South African Accreditation System (SANAS) further endorsed its quality-management systems as of high standard according to the International Standards Organisation’s requirements.

The Director of the NCL, Professor Derek Litthauer, said their laboratory – which is also approved by the World Health Organisation (WHO) – has again achieved the international testing standards. The cherry on top was that the NCL also received a certificate of Good Manufacturing Compliance (GMP) from the South African Health Products Regulatory Authority (SAHPRA). 

NCL is for Africa and the World 

Some of the factors that make the NCL an esteemed institution, is the fact that it is one of 12 laboratories worldwide to perform vaccine testing for the WHO; the NCL is the only vaccine-testing laboratory in the country that performs the final quality-control testing of all human vaccine batches marketed in South Africa on behalf of SAHPRA. 

For example, Prof Litthauer said that the influenza vaccine batches currently available on the South African market, were tested by the NCL for quality before authorising their release for sale to the public. This process is followed for all human vaccines used in SA.

 “In our role as vaccine-testing laboratory for the WHO, the NCL helps to ensure that the vaccines purchased through the WHO prequalification programme for international distribution to resource-limited countries, meet the high standards of quality, safety, and efficiency. 
The NCL was one of the first full members of the WHO NCL Network for Biologicals, which consists of full and associate members of regulatory authorities from more than 30 countries.

The NCL systems are world-class

Prof Litthauer said this achievement is recognition that their laboratory complies with specific international standards with respect to its quality-management system. 
“In practice, it means that the laboratory has all the quality systems in place to ensure high-quality test results. The GMP certification is a further step, meaning that laboratory testing is on the expected level for any pharmaceutical testing laboratory and manufacturer. It is a very strict certification.”

He further mentioned that the NCL is also licensed as a pharmaceutical manufacturer. “Although we do not manufacture, we have to comply with manufacturing standards.”
“It is rare for a pharmaceutical testing laboratory (such as the NCL) outside of a manufacturing context to qualify for both certifications. It means that the NCL complies with exceptionally strict standards for pharmaceutical labs anywhere in the world,” he said.
The certification provides the South African Health Products Regulatory Authority, the World Health Organisation, and other national control laboratories around the world, with the confidence that the test results from the NCL can be trusted.


There can be no compromise for quality 

The NCL Quality Assurance Manager, Mrs Marlena Visagie, said, “It is essential that the NCL complies with the highest international quality-assurance standards to ensure that all the lot-release operations, such as manufacturing review and quality testing, are performed in a reliable and reproducible manner.”

“There can be no compromise when it comes to the quality of medicines which are made available to the public,” she said.

“What makes this special, is that the NCL does not only comply with international ISO/IEC standards for pharmaceutical testing, but also with the additional GMP standards required by a pharmaceutical manufacturer. This means that the NCL must ensure that all its operations, including everything from the way documents are compiled and stored, to the maintenance of equipment and infrastructure as well as staff competency, are performed according to international guidelines.”

All NCL staff share vision of excellence

Prof Litthauer said the NCL has a staff complement of 15 technical, administrative, and support staff.  Four staff members have PhDs, and the rest of the technical staff have master’s or bachelor’s degrees or are trained as medical technologists. “At the moment, our biggest problem is to get enough suitable space to expand our testing,” he said.

Prof Litthauer said, “All the staff members at the NCL share the vision of excellence, which makes this kind of achievement possible.”
The NCL will host the third annual meeting of the WHO NCL Network in November of this year and will then be reassessed again by the WHO as part of the normal three-year cycle of assessments.  

News Archive

UFS venture cleans up acid mine drainage
2015-07-06

The system that puts oxygen back into the water.

Photo: Supplied

South Africa is one of the most important mining countries in the world, beginning in the 1870s. Although the mining industry has been responsible for significant development and employment, it pollutes the environment and waters sources. Through the joint effort of a well-known mining company, the University of the Free State, and the Technology Innovation Agency (UFS/TIA) SAENSE Group, a new treatment for Acid Mine Drainage (AMD) has been developed.

The system treats the major contaminants found in acid mining wastewater effectively.  
 
The UFS remediation systems use a reservoir tank into which the AMD is pumped. The water then flows passively (without using energy) to the Barium Carbonate Dispersed Alkaline Substrate (BDAS) system. The metals and anions in the AMD react chemically with the barium carbonate and precipitate (form solids). The solids stay in the tank while the clean water is released.

The efficacy and applicability of the research was demonstrated on site in Belfast, Mpumalanga where the team constructed a pilot plant in July 2014. This patented technology has treated 1 814 400 litres of Acid Mine Drainage to date with an outflow water quality that satisfies the South African National Standards (SANS) 241:2006 & 2011 regulations for drinking water.   

Rohan Posthumus from the (UFS/TIA) SAENSE Group said: “At this stage, we do not recommend that the water should be used as drinking water, but certainly it can lower water usage in mines while finding application in dust suppression of washing processes. The team would like to complete a full characterisation of the final released water. There are currently no toxic by-products formed, and even very basic filtration can make the outflow drinking water.”

Prof Esta van Heerden’s research group from the Department of Microbial, Biochemical, and Food Biotechnology has been working on AMD research for some time, but the development of the BDAS system was started in 2013 by post-doctoral student, Dr Julio Castillo, and his junior researcher, Rohan Posthumus.

The data from the BDAS system have led to two publications in peer-reviewed journals as well as a registered patent.

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