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21 May 2019 | Story Thabo Kessah | Photo Ian van Straaten
Dr Thandi Gumede
Dr Thandi Gumede graduated with a PhD in Polymer Science. She is from Intabazwe, Harrismith.

The Qwaqwa Campus of the University of the Free State was a hive of activity on 17 and 18 May 2019, when over 800 degrees, diplomas, and certificates were conferred on deserving achievers. These included six PhDs and 14 master’s degrees across the four faculties.

Congratulating the graduates on both days, was Africa’s youngest PhD and Industrial Psychology lecturer, Dr Musawenkosi Saurombe, and Prof Francis Petersen, Rector and Vice-Chancellor.

Be like heat

Dr Saurombe started her address by relating her school journey that saw her starting Grade 1 at age 5, thus later matriculating at the age of 15, having skipped Grades 3 and 10. She went on to emphasise the importance of building an honourable character.

“As a graduate, you will soon realise that your degree is useless if you do not have character,” she said to an attentive audience that continued to marvel at her remarkable school history. She encouraged graduates to be like heat that cannot be seen but can only be felt. “Noise can often be seen and heard, but it cannot be felt. However, while heat cannot always be seen, it is always felt. Be like heat and may your presence always be felt,” she said.

Do not focus on yourself

Prof Francis Petersen also encouraged graduates to look beyond their degrees by developing a set of critical values.
 
“For us as the university, this ceremony is not just about your degrees. It is about the values that you must live by,” he said. “As a graduate of the UFS, do not just believe what you are told. Ask questions and engage critically. Secondly, do not just focus on yourself. Remember that you are part of a community and it is your responsibility to make our world a better place for others. You need to be socially responsive to the needs of your community. Thirdly, remember that integrity plays a very important role. This will determine how others value you,” he said.

The two ceremonies also saw three current SRC members graduating. They are Lebohang Miya (BEd FET – Accounting and Business Studies), Duduzile Mhlongo (BA – Geography and isiZulu), and Mhlongo Sinemfundo (BA – Geography and isiZulu).

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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