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21 May 2019 | Story Thabo Kessah | Photo Ian van Straaten
Dr Thandi Gumede
Dr Thandi Gumede graduated with a PhD in Polymer Science. She is from Intabazwe, Harrismith.

The Qwaqwa Campus of the University of the Free State was a hive of activity on 17 and 18 May 2019, when over 800 degrees, diplomas, and certificates were conferred on deserving achievers. These included six PhDs and 14 master’s degrees across the four faculties.

Congratulating the graduates on both days, was Africa’s youngest PhD and Industrial Psychology lecturer, Dr Musawenkosi Saurombe, and Prof Francis Petersen, Rector and Vice-Chancellor.

Be like heat

Dr Saurombe started her address by relating her school journey that saw her starting Grade 1 at age 5, thus later matriculating at the age of 15, having skipped Grades 3 and 10. She went on to emphasise the importance of building an honourable character.

“As a graduate, you will soon realise that your degree is useless if you do not have character,” she said to an attentive audience that continued to marvel at her remarkable school history. She encouraged graduates to be like heat that cannot be seen but can only be felt. “Noise can often be seen and heard, but it cannot be felt. However, while heat cannot always be seen, it is always felt. Be like heat and may your presence always be felt,” she said.

Do not focus on yourself

Prof Francis Petersen also encouraged graduates to look beyond their degrees by developing a set of critical values.
 
“For us as the university, this ceremony is not just about your degrees. It is about the values that you must live by,” he said. “As a graduate of the UFS, do not just believe what you are told. Ask questions and engage critically. Secondly, do not just focus on yourself. Remember that you are part of a community and it is your responsibility to make our world a better place for others. You need to be socially responsive to the needs of your community. Thirdly, remember that integrity plays a very important role. This will determine how others value you,” he said.

The two ceremonies also saw three current SRC members graduating. They are Lebohang Miya (BEd FET – Accounting and Business Studies), Duduzile Mhlongo (BA – Geography and isiZulu), and Mhlongo Sinemfundo (BA – Geography and isiZulu).

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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