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04 November 2019 | Story Valentino Ndaba | Photo Charl Devenish
SK Luwaca at UFS Safety Summit for off-campus students
Sikhululekile Luwaca, leader of the UFS Safety Champions, addresses a delegation at the Higher Education Safety Summit from 18-19 October 2019 at the Bloemfontein Campus.

A meeting of minds over student safety recently took place at Kovsies. The Higher Education Safety Summit saw a cohort of 165 students from the University of the Free State (UFS), Central University of Technology and Sol Plaatje University, collaborating with the heads of Protection Services from the respective institutions to devise a safety blueprint specifically focusing on the off-campus environment.

“The rental tribunal came on board to assist with rental disputes between students and landlords, in addition to accreditation issues being discussed,” Sikhululekile Luwaca, former SRC President of the Bloemfontein Campus and leader of the UFS Safety Champions that form part of the Unit for Institutional Change and Social Justice.

Luwaca further said that the Mangaung Metropolitan Municipality also committed to assist the universities in addressing crime and enforcing by-laws. “A strategic safety plan was developed around spatialisation and zoning of student communes, developing a system that will assist universities to establish where students stay by using technology such as geographic information system (GIS),” he added.

What were the objectives of the summit?
Being the first of many to come, the summit set out clear objectives which all stakeholders have committed to work tirelessly to achieve, both in the short and long term.

The goals of the summit were threefold. Firstly, the intention was to build capacity between students and staff of all institutions involved to implement programmes by transferring the skills and knowledge between one another.

Secondly, the idea was to gather and consolidate input from the various higher-learning institutions and by so doing diversify the solutions. Thirdly, the purpose of the summit was to create an official platform where partners may consult on interventions that will ripple from the local, to the provincial and further to national level.

Andiswa Msomi, Spatialisation Group Leader and the Safety Champions’ administrator said she appreciated the shift in perspective that the summit brought. “The summit brought to my attention that sometimes we focus so deeply on one aspect of a problem that we end up not seeing alternative solutions. Due to active participants, new solutions came up, new ideas were brought forth and more importantly, we were able to get other institutions on board,” she said.

What are some of the tangible outcomes?
Going forward, an internal report which focuses on crime prevention measures will be presented to all UFS stakeholders. An external report, which will be submitted by the Safety Champions to the government in January 2020, is expected to be integrated into the Provincial Crime Prevention Strategy.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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