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28 November 2019 | Story Legopheng Maphile | Photo Supplied
Open Access
Staff from the Library and Information Services of the UFS and the CUT

The Library and Information Services of the University of the Free State (UFS) and the Central University of Technology,Free State (CUT) jointly hosted an Open Science Colloquium on 19 November 2019. The colloquium was in response to the national and international developments in what is referred to as ‘the Open Access 2020 (OA2020) movement’. This movement calls on all parties involved in scholarly communication to take action to make their scholarly outputs open and freely available to all citizens of the world. It is a move against the current subscription-based model of publication, which has proved to be costly and unsustainable, and which limits access to knowledge to a few, making it unacceptable.

Welcoming more than 200 delegates to the UFS, Ms Betsy Eister, Director: Library and Information Services, referred to OA2020 as a disruption in the publishing arena.

Endorsing the Berlin Declaration on Open Access to Knowledge in the Sciences and Humanities

The colloquium comes as an endorsement of the Berlin Declaration on Open Access to Knowledge in the Sciences and Humanities that the two universities signed eight years ago. As signatories, the UFS and CUT have committed to the wide and free dissemination of its scholarship by means of open access platforms. This declaration was confirmed by the Rector and Vice-Chancellor, Prof Francis Petersen.  

“When the UFS signed the Berlin Declaration on Open Access to Knowledge in the Sciences and Humanities in 2011, this university committed itself to the wide and free dissemination of its scholarship by means of open access platforms. At that point, we have already made that commitment to open access platforms.”

Open access vs subscription

Prof Petersen said challenging the current status quo will bring equity into the system, which  will “ensure that our younger cohort of researchers and scholars have the ability to freely conduct research, to freely access material, so that we can produce high-quality researchers and scholars for our system”. 

Also present was Prof Ahmed Bawa, Chief Executive Officer of Universities South Africa, who echoed Prof Petersen’s message by making a case for management, researchers, libraries and research funders to work together to make OA2020 a reality. “These discussions are very important because it provides us with an opportunity to build international consensus on these things, which is critical in moving forward.”

Prof Ahmed Bawa

Prof Ahmed Bawa, Chief Executive Officer of Universities South Africa addressed delegates on the importance of open access. 

Mr Glenn Truran, Director of the South African Library and Information Consortium (SANLiC), and Ms Eister addressed the national and local roadmaps, respectively. SANLiC, a consortium that negotiates deals for electronic resource subscriptions on behalf of all 26 public universities and eight research councils, has already started transformative agreement negotiations with international publishing company Taylor and Francis. 

The colloquium ended with a declaration signed by members present, hoping that it would be signed by all concerned as a commitment to taking action towards open access.  The two universities will ultimately sign the OA2020 Expression of Interest.

• The UFS and CUT Libraries are thankful to Mr Gareth O’Neill and UFS colleagues (Mr Charlie Molepo and Mrs Cornelle Scheltema-Van Wyk), who shared information with the attendees on transformation agreements (also referred to as Plan S) and AmeliCA, respectively. Plan S deals with transformation agreements to be signed with publishers, which are about negotiations with publishers to change from subscription-based to open-access journal publishing models. Mr Molepo and Mrs Scheltema-Van Wyk showcased the open access model that the UFS Library has already implemented, which is what AmeliCA is all about. This involves the publication of nine accredited UFS journals on the Open Journals System platform, which enhance its discoverability and accessibility. It was also a pleasure to listen to Prof Abdon Atangana from the UFS Institute for Groundwater Studies – a classic example of an activist and beneficiary of open access publishing – who was recently named as one of the top-10 cited researchers in the Web of Science, thanks to open access publication.

Betsy Eister
Betsy Eister, Director: Library and Information Services at the UFS. 


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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