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16 October 2019 | Story Valentino Ndaba | Photo Rulanzen Martin
Dr Thuli Mphambukeli and Victor Okorie
Water is a fundamental human right, says Dr Thulisile Mphambukeli, (left) Senior Lecturer at the Department of Urban and Regional Planning. On the right is Dr Victor Okorie.

Research shows that “access to water and food remains critical to the survival and stability of any nation”. This is according to a team of academics that has been hard at work exploring ways in which to secure water and food in Brazil, Russia, India, China and South Africa (BRICS nations).

These scholars from the University of the Free State (UFS) and North-West University recently published a paper titled: Exploring the Political Economy of Water and Food Security Nexus in BRICS. Dr Thulisile Mphambukeli, Dr Victor Okorie, and Prof Samuel Amusan are members of the Food Security Research Cluster of the South African BRICS Think Tank that has been fervently tackling the water and food in(security) challenge.

Water as a key to social justice 

The team argues that unequal access and distribution of water has in the past led to violent conflict. The paper cites Qwaqwa as one of the many areas affected by water-service protests in the recent past. “Water and food crises are worsening thanks to the intensification of climate change, rapid urbanisation, nutrition transition and population growth. Solutions to these crises partly lie in cooperation and collaboration among nation states, regional economic commissions, and global power brokers.”

What are some of the local solutions? According to the scholars: “For agronomic and husbandry practices, there is a pressing need for research activities on innovative ways of supplying water to crops and animals such that water loss through evaporation and run-off is significantly reduced. 

“Similarly, research activities on redesigning toilets, especially the urinary section – where more than nine litres of water are used to flush less than one cubic centimetre of urine – are timely in the context of managing the water and food security nexus crises.”

Improving livelihoods

In an effort to achieve food security, BRICS aims to stimulate domestic capacity for production. Food and nutrition security cannot be achieved without water security, and vice versa. 

It is evident that the water and food insecurity issues are complex. However, concerted efforts are being made by various sectors to solve these challenges and improve the livelihoods of urban and rural citizens within BRICS nations.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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