Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
16 October 2019 | Story Valentino Ndaba | Photo Rulanzen Martin
Dr Thuli Mphambukeli and Victor Okorie
Water is a fundamental human right, says Dr Thulisile Mphambukeli, (left) Senior Lecturer at the Department of Urban and Regional Planning. On the right is Dr Victor Okorie.

Research shows that “access to water and food remains critical to the survival and stability of any nation”. This is according to a team of academics that has been hard at work exploring ways in which to secure water and food in Brazil, Russia, India, China and South Africa (BRICS nations).

These scholars from the University of the Free State (UFS) and North-West University recently published a paper titled: Exploring the Political Economy of Water and Food Security Nexus in BRICS. Dr Thulisile Mphambukeli, Dr Victor Okorie, and Prof Samuel Amusan are members of the Food Security Research Cluster of the South African BRICS Think Tank that has been fervently tackling the water and food in(security) challenge.

Water as a key to social justice 

The team argues that unequal access and distribution of water has in the past led to violent conflict. The paper cites Qwaqwa as one of the many areas affected by water-service protests in the recent past. “Water and food crises are worsening thanks to the intensification of climate change, rapid urbanisation, nutrition transition and population growth. Solutions to these crises partly lie in cooperation and collaboration among nation states, regional economic commissions, and global power brokers.”

What are some of the local solutions? According to the scholars: “For agronomic and husbandry practices, there is a pressing need for research activities on innovative ways of supplying water to crops and animals such that water loss through evaporation and run-off is significantly reduced. 

“Similarly, research activities on redesigning toilets, especially the urinary section – where more than nine litres of water are used to flush less than one cubic centimetre of urine – are timely in the context of managing the water and food security nexus crises.”

Improving livelihoods

In an effort to achieve food security, BRICS aims to stimulate domestic capacity for production. Food and nutrition security cannot be achieved without water security, and vice versa. 

It is evident that the water and food insecurity issues are complex. However, concerted efforts are being made by various sectors to solve these challenges and improve the livelihoods of urban and rural citizens within BRICS nations.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept