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28 October 2019 | Story Leonie Bolleurs | Photo Anja Aucamp
Dr Brain van Soelen and Prof Pieter Meintjies
UFS scientists, Prof Pieter Meintjes and Dr Brian van Soelen, are part of the prestigious H.E.S.S. collaboration that recently published in Nature Astronomy.

Think of an object with a mass exceeding that of the Sun, squeezed into a volume of a sphere with the radius of a city like Bloemfontein. This very dense, compact object, known as a pulsar, is also a great source of energy. According to Physics Professor, Prof Pieter Meintjes, this pulsar (neutron star produced in supernova explosion) is also a key element of a recently submitted paper in Nature Astronomy.

Prof Meintjes and Dr Brian van Soelen, Senior Lecturer, both from the Department of Physics at the University of the Free State (UFS), were part of the High Energy Stereoscopic System (H.E.S.S.) collaboration of 220-plus scientists worldwide who worked on the paper Resolving the Crab pulsar wind nebula at tera-electronvolt energies, published in the prestige journal Nature Astronomy. 

According to Prof Meintjes, the fact that the paper was accepted for publication in Nature Astronomy testifies of the importance of this finding in the high-energy astrophysics community.

Powerful generators of electricity

He elaborates on the study: “The name pulsar originates from the fact that rotating neutron stars produced in supernova explosions produce beams of radiation, much like a lighthouse. Every time the beam intersects the observer’s line of sight, the observer receives a pulse of radiation.”

“As a result of this enormous mass squeezed into a small volume, these objects have the same density as that of an atomic nucleus. These objects (very dense pulsars) spin very rapidly and have enormous magnetic fields; for example, the pulsar at the centre of the Crab Nebulae spins around its axis once every 33 milliseconds (millisecond: one thousandth of a second) and possesses a magnetic field strength of the order of one tera-Gauss (tera – million x million). For comparison, the average strength of the Earth’s magnetic field is 0.5. Gauss and the magnetic field strength on the Sun ranges between 1 000 and 4 000 Gauss.”

“Because of this very super-strong rapid-spinning magnet, enormous electric fields are induced that can accelerate particles such as electrons and protons to energies in excess of one tera-electronvolt (optical light that are emitted by an ordinary lightbulb has energies of the order of one electronvolt).”

Prof Meintjes continues: “This means that these fast-rotating neutron stars are extraordinary powerful generators of electricity, which fills the surrounding cloud (supernova remnant) with super-high energy-charged particles that can produce, in turn, very high energy gamma rays through various processes such as synchrotron radiation and inverse-Compton radiation, to name a few.”

H.E.S.S. collaboration 

Above one tera-electronvolt, the gamma rays are detected by huge ground-based telescopes such as H.E.S.S., utilising the Earth’s atmosphere.

“When these high-energy gamma rays enter the atmosphere, they produce showers of super-relativistic particles that produce Cherenkov light – detected by the telescope. The technique is called the Atmospheric Cherenkov Technique (ACT).”

HESS
The High Energy Stereoscopic System. (Photo: Supplied)

“The H.E.S.S. gamma-ray collaboration is but one collaboration that has studied this source intensively over the past couple of decades or so.  Being the most powerful gamma-ray telescope facility currently operational, very careful analysis of the data managed to reveal that the gamma-ray emitting region inside the nebula is about 10 times bigger in size than the region where the x-rays are emitted within the nebula.” 

“This has solved a long-standing question as to how big the gamma-ray emitting region within these supernova remnants are, compared to the region where the x-rays, for example, originates,” says Prof Meintjes. 

Both Prof Meintjes and Dr Van Soelen are members of this prestigious H.E.S.S. collaboration. Their participation in this project, together with scientists from universities such as the University of Oxford, the University of Leicester, and the University of Bordeaux, opens up valuable research opportunities for UFS postgraduate students to enter the international stage and interact with the best scientists in the world.

They are also members of the editorial board responsible for the internal review of research papers before being submitted to more prestigious journals, for example, Nature Astronomy. Dr Van Soelen is also a coordinator of multi-wavelength follow-up observations within the H.E.S.S. collaboration. 

This is the second time that Prof Meintjes published in Nature Astronomy. Previously, he was co-author of a paper on emission from a white dwarf pulsar, showing that fast-rotating white dwarf stars could in fact mimic emission from neutron star pulsars. He developed the theoretical model reported in that paper, explaining the multi-wavelength emission from radio to X-ray energies.


News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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