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18 October 2019 | Story Thabo Kessah | Photo Tshepo Moeketsi
Prof Pearl Sithole
Prof Pearl Sithole says higher education needs to create space for Africa to be contributors and innovators of knowledge.

“Excellence is my main priority. For me, excellence means mastery of cross-communicable science and liberation of intellectual creativity that is free of mere complacency and acknowledging the right to analyse from where we stand. I am unapologetic about indigenous knowledge being the basis for scientific advancement.” This is how the newly appointed Vice-Principal: Academic and Research, Prof Pearl Sithole, sums up her vision and plan for academia and research on the Qwaqwa Campus. 

She believes that the human mind is geared towards ‘seeking and constantly explaining itself in the service of innovative change.’ 

“With this service of innovative change fully realised, the Qwaqwa Campus will be able to produce students who can analyse, innovate, and solve real social and world problems. For me, this is the University of the Free State graduate I pine to see – and there had better be truth to the ‘free’ part of this intellectual soul! I see Qwaqwa as a site for this intellectual innovation catalyst,” she said.

Social anthropologist

Prof Sithole is a Social Anthropology graduate with both master’s and PhD degrees from the University of Cambridge in England. “I stumbled upon Anthropology as part of my three majors at the then University of Durban-Westville. This discipline confessed its previous conceptual sins in a way that inspired change! From the exploration of human origins, to economic and political developments, and that was Anthropology. I was just absolutely taken by its acknowledgement of the intellectual project being socio-culturally rooted,” she said about her chosen area of study.

“I have always been inspired by Archie Mafeje’s work. I was motivated by Bernard Magubane’s scholarship, and I marvelled at the rigour of Oyeronke Oyewumi and Marilyn Strathern in feminist discourse. I mention these, because they inspire intellectual passion in me and I eventually met them,” she added.

Higher education in SA

She believes the higher-education sector is succumbing to streamlining methods, uninformed processes, and very little impact. “Like in government, higher education should not suffer from reduction of people into statistics, interventions into annual performance plan targets, and planning and monitoring into sanitised expenditure against targets. I see the shortage of relevance, responsiveness, and humanness; as well as ‘being captured’ by the latest fashions of doing rigid academe as the major challenges of higher education in South Africa today. We need to liberate our own innovative potential. We really need to create space for Africa to be contributors and innovators of knowledge,” Prof Sithole, the author of Unequal Peers, said.

She is, however, optimistic about the future of higher education in South Africa. “The day that we will have our innovation systems and systems of defining excellence – liberated from merely kneeling before the altar of Westernisation – we will gain integrity both conceptually and instrumentally in terms of responding to a society that is waiting for higher education to solve societal problems. The solution is to let those who see this truth continue to produce the knowledge despite being less than pleasing to the average scientific oversight bodies steeped in conventional Western validation.”

Research interests

Prof Sithole was previously employed with the Public Service Commission as a commissioner, a position she held from 2015 to August 2019. Prior to that, she worked at the University of KwaZulu-Natal as an Associate Professor of Community Development from 2010 to 2015, and at the South African Human Sciences Research Council (HSRC) as a senior researcher from 2006 to 2010. Her research interests and areas of expertise are governance, gender and development, analysis of social inequality, and the politics of knowledge production.


News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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