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21 October 2019 | Story Thabo Kessah | Photo Tshepo Moeketsi
Qwaqwa research research
Mamokete Mokhatla (SRC: International Students Council), Pulane Xaba (Assistant: Afromontane Research Unit), Dr Hagenmeier, Morena Ntsane Mopeli, Prof Pearl Sithole, Chief Mlati, Kanego Mogotsi (Internationalisation: Qwaqwa Campus), and Prof Joseph Francis.

Communities are beginning to wonder if universities exist for themselves or for their communities. This is the view shared by Prof Pearl Sithole, Campus Vice-Principal: Academic and Research, during the opening of the two-day Travelling Seminar that was recently hosted on the Qwaqwa Campus. 

Research in communities

“This event is well-placed, considering what many communities are currently going through. We must ask ourselves what we are doing with and for our communities. We must be careful to not only reap data from them, but to be scientific in a way that accommodates our communities and allows the African and indigenous agenda into the world of science,” she added.

Providing background to the concept of homestays, the Director: Institute for Rural Development at the University of Venda, Prof Joseph Francis, acknowledged the role played by communities in research.

 “This seminar seeks to develop a testable framework for homestays; a concept enabling postgraduate students to be placed with rural families while conducting research in the area. It is also aimed at giving birth to a vibrant, community-based rural and regional development network connecting grassroots communities, business, government, and non-governmental stakeholders,” he said.

“We do not only train students for local deployment and within national borders. It is important to produce an ‘all-weather’ graduate who stands out wherever they are. Graduates must ask themselves, ‘what in me stands out among the rest?’ As a student and researcher, never see yourself as being confined to the space where you are,” he added.

Students as ambassadors

Cornelius Hagenmeier, Director: Office of International Affairs at the University of the Free State, said for internationalisation to work, it has to be inclusive and create student ambassadors. “As this seminar will show, our networks of stakeholder communities go beyond the national confines and borders. We must strive, through this project, to create ambassadors of the university, of communities, of the broader South Africa and Africa,” he said.

Participants in the seminar were academics and postgraduate students from both the Universities of the Free State and Venda. Also present were community and traditional leaders from Qwaqwa and the Vhembe District in Limpopo. 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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