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02 October 2019 | Story Anneri Meintjes | Photo Charl Devenish
Anneri Meintjes
Anneri Meintjes from the Centre for Teaching and Learning at the UFS.

The #FeesMustFall student-led movement started in 2015 to protest against increasing student fees and to call for increased government funding of universities. At the end of 2016, the protests led to mass disruption of academic activities in higher-education institutions countrywide. Some universities, including the University of the Free State (UFS), suspended academic activities for extended periods which necessitated online and blended learning approaches (the combination of face-to-face and online learning) to complete the academic year. In most cases, these methods were unplanned and unstructured, and knowledge gaps in good blended learning practice were identified.

The Carnegie Corporation of New York funded a two-year research project in collaboration with the University of Pretoria, UFS, University of Cape Town and University of Johannesburg to investigate the use of blended learning at the end of 2016, during the campus disruptions, as well as how these respective institutions used blended learning in 2017.

The prohibitive cost of data in South Africa means few of our students have access to the internet off-campus. The most recent data on UFS student digital identity shows that only 21% have consistent, reliable access to the internet at home. This is a challenge not only for the UFS but for all universities in the country.

“For technology to be used in a way that contributes to learning and teaching, we needed to investigate what works well and what does not, considering our contextual challenges” says Anneri Meintjes from the Centre for Teaching and Learning, who was the principal researcher for the UFS on this project. In the first phase of the research, she wrote a case study on the UFS’ approach to blended learning during and after the protests in 2016. The findings of this phase of the research were presented at a national convening of higher-education institutions across South Africa.

In the second phase of the research, the four participating universities produced open educational resources on good, blended learning practice to share with universities countrywide. The UFS was responsible for the development of online assessment resources and general best-practice guidelines for the use of blended learning. Anneri says: “While we had laid solid foundations for the effective use of online assessment at the UFS prior to 2016 through the investment in online assessment software and staff development in online assessment design, we learnt many valuable lessons during that time. It provided momentum for the establishment of formal online assessment procedures and refinement of best-practice guidelines. This research project gave us an opportunity to share our work on a national platform.” The number of lecturers that use online assessment in their modules has grown considerably at the UFS since 2016. In 2016, 211 online assessments were completed on Questionmark (UFS online assessment programme) and in 2018, this number had grown to 743. Institutional Blackboard use data shows that at least one online assessment tool is used in 47% of all modules on Blackboard.

Resources developed by the other participating institutions include a self-evaluation app that academics can use to reflect on their existing blended learning practices, and an online utility that assists lectures and course designers to plan blended learning modules.

Anneri also coordinated the development of the national website, which was launched at the Flexible Futures conference hosted by the University of Pretoria on 9-10 September 2019. The website and resources were praised at the conference for being a timely response to a critical need in the higher education community in South Africa.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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