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04 September 2019 | Story Leonie Bolleurs | Photo Charl Devenish
Jon Jacobson
Delivering the 31st Sophia Gray Memorial Lecture and Exhibition in Bloemfontein, was Jon Jacobson from Metropolis Design in Cape Town.

What is inside and what is outside? What is coming alive in the light? Minimalism. Hugeness. Shadows. Soft. Art. Complex. Conversation. Ambiguity. Clarity. All phrases and words used by the most recent Sophia Gray laureate, Jon Jacobson from Metropolis Design in Cape Town, to describe aspects of his work.

He delivered the 31st Sophia Gray memorial lecture in Bloemfontein. The name of his lecture at this prestigious event, organised by the UUFS Department of Architecture, was in [de] finite. Jacobson is the first graduate in the department’s MArch with Design.

Nature plays a big role in many of his projects, with a blurred distinction between the inside and the outside of the structures he builds. His designs fulfil the desire of a union with nature. 

A detailed investigation

Jacobson creates places and spaces to celebrate being. “Architecture is undeniably art, but it is also embodied in the completeness of the lived moment,” he says. 

Every project starts with a detailed investigation. “What social theory will we engage with? How progressive is it? What attitude will we take to the environment, to the theory of family? What other personal concerns will we be worried about? It is important to engage critically with this information. Important to build a philosophical base for each project,” says Jacobson.

He also believes it is important to consciously ensure that form follows idea with the same intensity that it follows function and that it does not blindly follow other form. 

At Metropolis, Jon and his team are client centred in their approach to design. Jon explains the process: “Some of the content is brought from the client’s personal and social aspiration and some from contemporary architecture culture, but the most potent component is the hidden set of ideas that emerge from our own engagements with the living world such as popular science, geology, art, music, literature, philosophy, theology, mysticism, and many others. And this emerges in the hidden sense of the word, in its architecture content.”

Content approach to design

In house design, Jon categorises the content that informs the architecture of the house: content pertaining to the individual, their philosophy, values and beliefs, content derived from culture, architecture and the arts, passion, religion, politics, and content referring to the natural world and its processes. Content from each of these spheres is present in any of his work. 

Jon says a major implication of a content approach to design is that it requires a design framework that is largely operative at a level of idea rather than at the level of form. This contributes to creating architecture rather than just buildings. 

His design method allows conscious control over the relationship between the ideas, the forms, and the poetics of the projects. “And at any point in the building process, it is possible to trace back and to critically assess whether any particular form is aligning with the core ideas of the project,” Jon indicates. 

Jon’s first taste of grappling with the infinite of architecture was with a garden pavilion he built for rest and relaxation. “For the first time I felt that we integrated planning, content, sight, programme, structure, and materiality into one unified whole that was expressed with a minimum of means and that was more than just the sum of its part,” he states.

He strongly believes that the individual is at the centre of every architectural project. He says the belief systems, type of social needs, family dynamics, physical habits, and spatial practices of their clients need to be investigated in detail in order to facilitate a meaningful spatial experience.

He continues: “We see our role as designers to saturate the environment with the meaning that enhances our clients’ daily experience in every possible way – from the ergonomic and the practical to the spiritual. In the process, the logics and tradition of architecture and the ego of the architect sometimes need to make way for human need and aspiration.”


News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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