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12 September 2019 | Story Ruan Bruwer | Photo Varsity Sports
Netball
Jana Scholtz, goal defender and playing in her first year as a regular starter, has been a solid performer for the Kovsie netball team in Varsity Netball.

The building blocks are starting to form a solid basis from where Kovsies can launch an attack to defend the Varsity Netball title they won in 2018. This is according to Karin Venter, one of the team’s assistant coaches.

After losing their first encounter to Tuks, they registered wins over the University of Johannesburg, Tshwane University of Technology, and the North-West University. The match against the Maties in Bloemfontein on 23 September 2019 – the last in the group stage, should determine which of the two teams will book a home semi-final along with Tuks.

“Yes, that is the crucial one,” said Venter, the team’s defensive coach. Her counterpart at the Maties is Adéle Niemand, with whom Venter combined as defenders at Kovsies for several matches in the mid-2000s. Apart from the Maties, the women of the University of the Free State still have to face the Madibaz and the University of the Western Cape (both in Pretoria on 15 and 16 September 2019).

“The combinations are starting to form a unit and our confidence is on the increase. Now we are looking for consistency in our performances.”

According to Venter, they were hit hard by goalkeeper Ané Retief’s injury, which kept her out of the first two matches. This meant that they had to start against Tuks with a first-year student, Chanel Vrey.

“It was tough, but I’m impressed with the way in which she, Ancia Pienaar, and Jana Scholtz – who are all youngsters – stepped up.”

Venter is responsible for the analyses and recons to assist players.

“The programme we are using provides us with all the required footage. You can make notes on it and send these clips to players, which means you don’t have to sit next to a player to explain something. We also provide them with notes and sketches of opponents’ playing patterns, which they must work through as part of their preparation.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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