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10 September 2019 | Story Rulanzen Martin | Photo Rulanzen Martin
Lingustics
Delegates at the workshop were provided opportunities that many larger conferences do not offer.

The growing body of work examining microvariation in African languages prompted Dr Kristina Riedel and Dr Hannah Gibson, from the University of Essex and research fellow, to work on a research project, “Variation in Sesotho and Setswana as spoken in the Free State”, to document the dialectal variation in the languages as it is spoken in the province. 

“Dr Gibson and I have a joint research project which is funded by a Newton British Academy mobility grant,” says Dr Riedel, Head of the Department of Linguistic and Language Practice at the University of the Free State (UFS).

The duo hosted a workshop on morphosyntactic microvariation (small structural differences that can be observed between closely related languages or dialects) on the UFS Bloemfontein Campus, as part of the Newton Fund research project.  

Research focus on dialectal variation 

Dr Riedel says there has been some linguistic work on both of these languages. “But for Sesotho, linguists have noted that there is no dialectal variation. This seems hard to believe given the size of the population who speak the language,” she says. 

They are looking at speakers in the Free State province for differences in both languages. Speakers themselves also report awareness of dialectal differences and variation between different regions. “We’re also interested in whether they have influenced each other – particularly in places where people speak both of these languages on a day-to-day basis, such as Thaba ’Nchu and Bloemfontein,” Dr Riedel says.

Dr Riedel believes that in the context of an African university it is important to contribute to the development, teaching and support of African languages. “Research on African languages can play an important part of this picture. Furthering our knowledge and understanding of African languages from a linguistic perspective also contributes to our understanding of the world’s languages and linguistic diversity.” 

Workshop creates space for training and skill sharing

The aim of the workshop was to bring together researchers, students and language practitioners to “provide them with some of the insights and training that is helpful when looking at morphosyntactic microvariation”, Dr Riedel says.

The workshop was conducted in two sets. At the first workshop the emphasis was on training and sharing of skills and the second part focused on more research-related presentations. 

The workshop, which took place on 19 July 2019, was attended by delegates from numerous local institutions (Rhodes University, University of the Western Cape and Stellenbosch University) as well as universities in the rest of Africa including the University of Malawi, Dar es Salaam University College of Education and Makerere University in Uganda. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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