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05 September 2019 | Story Prof Francis Petersen (UFS Rector and Vice-Chancellor)

In light of the ongoing violence against women, and recent surge in femicide in South Africa, the University of the Free State (UFS) recommits itself to challenge, fight and eradicate all forms of gender-based violence on its campus and in the country.

The recent rape and murder of 19-year-old Media and Film Studies student at the University of Cape Town (UCT), Uyinene Mrwetyana, and the murder of University of the Western Cape (UWC) student, Jesse Hess, are painful reminders of the pervasive nature of misogyny and patriarchal violence that impedes the freedom of women/womxn in South Africa. The UFS stands in solidarity with UCT and UWC, and all other South African universities that are currently steeped in this national crisis pertaining to gender-based violence.

The UFS perceives this as an enduring manifestation of patriarchy that results in women’s/womxn’s subordination, inequality, and violation of bodily integrity. These horrific events underscore the extent to which attempts to address women’s/womxn’s inequality and gender-based violence nationally, and more pertinently at universities, have failed. Recent discussions have underscored the issue of ‘belonging’ as a concern in Higher Education contexts. Belonging is often couched in the language of ‘access’ and ‘transformation’. However, these terms often provide limited substantive change for students who experience a sense of marginalisation and alienation at South African universities. Decolonisation discourse challenges the nature of hegemonic knowledge production that excludes voices of alterity.

Epistemic violence is central to decolonisation discourse referring to the nature of hegemonic knowledge production that excludes voices of alterity. The extent to which knowledge production manifests in universities is, however, not only white and Western, but also male and masculine. South African universities are therefore confronted again with the urgency of recognising and responding to the issue of women’s/womxn’s subordination, with specific emphasis on their safety and freedom.

The UFS is committed to creating a university space where all our students feel that they belong, by broadening current epistemologies and including women’s/womxn’s voices and lived experiences. More pertinently and in a practical manner, curriculum change should include diverse intellectual perspectives and incorporate an ethics of care in teaching practices. The UFS acknowledges that more must be done as a space of higher learning to investigate the causes that underlie the continuance of sexual violence against women/womxn.

On Friday 6 September 2019, the UFS held a day of mourning, standing in solidarity with other universities in their attempt to respond to the present crisis. In mourning Uyinene and Jesse’s death and all other victims and survivors of gender-based violence, the university will critically self-reflect on the multi-layered demand for transformation and consciousness needed for deep change.

The UFS calls on the Department of Higher Education, civil society, the business sector and all others to actively contribute to efforts that will eradicate gender violence. As the UFS, we call specifically on the City of Bloemfontein, the mayor, members of local government, South Africa Police Service and all inhabitants to assist us in making the city safe for all.

Prof Francis Petersen
Rector and Vice-Chancellor
University of the Free State
5 September 2019


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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