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02 September 2019 | Story Thabo Kessah | Photo Thabo Kessah
Eunice Lebona
Eunice Lebona sees herself as a ‘perfectionist procrastinator.’

She is literally the beginning and the end of students’ academic careers on the Qwaqwa Campus, as she welcomes each one of them with an application form when they arrive and ensures that they enjoy their moment in the Rolihlahla Mandela Hall when they graduate. She says she derives all the pleasure and creativity from ‘last-minute crunch’. For those who have interacted with her, she epitomises excellence in the execution of her duties, but many would not know that she is a procrastinator. 

She is Eunice Lebona, Assistant Director: Student Academic Services.

Childhood lesson

‘Ausi Eunice’, as she is affectionately known, credits her grandmother for valuing accountability, her most prized childhood lesson.

“My grandmother raised me and as the oldest grandchild, I learnt the value of accountability at an early age; this has been the cornerstone of my life and career.  Although it is valuable to have support around you, standing on your own two feet is critical, because you will not know when that support might not be available,” she said. 

Working with students comes naturally to her, as she is inspired by progression and achievement.

Personal inspiration

“Getting to higher echelons than previous accomplishments, is my inspiration.  My successes are energisers to achieve the next steps on unique and distinctly different notes than the previous ones. It is this same notion that builds my view, that – as the University of the Free State – we need to see women representation in leadership on a greater scale, as well as respect for their spaces of delivery.”

When asked about the one thing that very few people knew about her, she said: 
“I am a procrastinator. In fact, I am a perfectionist procrastinator. Although procrastination is not good, the last-minute crunch is stimuli to ideas that I would normally not dream of in my comfort mode,” Lebona insists.

What is success?

She defines success as “inner gratification which is the result of the outcomes I had to deliver on”.  She adds: “Witnessing the success and motivation of others from the small contributions I have made in their lives, is all the success that resonates with me. Respect and humility go a long way in attaining success. As indicated earlier, my grandmother played a crucial role in my upbringing and instilled in me the philosophy entrenched in Luke 6:31 that says: ‘Do unto others as you would have them do unto you.’ That has been my motto since her passing away”.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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