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30 April 2020 | Story Baptiste Becret | Photo Supplied
Baptiste Becret.

Since the approval of the University of the Free State (UFS) internationalisation strategy for 2018-2022, the UFS community and staff members of the Office for International Affairs (OIA) have been working hard to try and realise the goals stated in the strategy. The policy states “the university's’ commitment to developing curricula that are locally relevant, globally competitive and connect to multiple knowledge paradigms”. Furthermore, “We expect that the new internationalisation strategy will advance the international positioning of the university, and synergise the existing rich international activities into intentional, comprehensive internationalisation processes”.

In an effort to realise the said expectations through the university’s inbound mobility programme, the Department of Afrikaans and Dutch, German and French in the Faculty of the Humanities has hired Baptiste Becret, an exchange student from French partner university, Science PO Bordeaux, as French tutor for the first semester of 2020. This collaboration by the two departments endeavours to achieve the university’s vision of developing its students’ international and intercultural competencies through internationalisation at home. Equally, this initiative speaks to a critical aspect of internationalisation, the “purposeful integration of international and intercultural dimensions into the formal curriculum for the UFS students within the domestic learning environment”.

Being the only Frenchman on campus

“I was the only Frenchman on campus and at the university, which I rather enjoyed. I learned at the beginning of this year, in January, that I could share my culture and language by helping students participating in the first- and second-year French courses at the university. For my part, I was attached to the Faculty of the Humanities. I've already had experience as a tutor in France, so I wasn't very stressed at the idea of being in front of a class. I enjoyed trying to teach my mother tongue. My contact with the French teacher was good. He gave me a lot of freedom to do the activities I wanted to do.

I didn't think that passing on my knowledge to the first-year class would be so difficult. Indeed, for some of them, they have never spoken a word of French. But the atmosphere improved from class to class after a shy start. I hope I was able to help them as best I could. In any case, I was very happy to teach them and to assist them in their various difficulties with the language. For the second-year class, the atmosphere was a little different. The class was smaller, the students already knew each other well, and they were pretty close. Additionally, their language level was already good. 

All this to say that being a French tutor was a great experience. It was enriching for both parties (students and me). Of course, I tried to do the best I could, and I took advantage of the free time my schedule gave me to share a little bit of my home country. So, I advise future international students – if they feel comfortable with that – to give it a try. It's only two hours a week with a little bit of extra money. Finally, I would like to thank the International Office for informing me of this opportunity, the people involved in the programme, including my coordinator, the French teacher, and especially the students who have been super cool to me.” 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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