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01 April 2020 | Story Valentino Ndaba | Photo Valentino Ndaba
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Takudzwa Nyamunda represented the UFS at the latest Commonwealth Futures Workshop where youth from across the globe convened to develop solutions for social issues.


Gender-based violence, global warming, and inequality are just some of the challenges faced by societies internationally. Examining this and other topics Takudzwa Nyamunda represented the University of the Free State (UFS) at the Commonwealth Futures workshop which convened at the Durban University of Technology (DUT). Participants from 13 nations gathered from 11-14 March 2020 to discuss the future of the world.
 
Over the course of four days, student leaders explored ways of bringing peace and nonviolence to the challenging issues we are facing in the world, under the theme: Reimagining Peace. The workshop was organised by the DUT in collaboration with the Association of Commonwealth Universities (ACU) and the British Council. 

The voice of young people 
International forums such as the Commonwealth Futures workshop are to Nyamunda a prerequisite in these modern times. Nyamunda believes that global problems warrant global solutions. According to the Industrial Psychology Master’s student, young leaders have a crucial role to play in nation-building. 

“My experience proved to me that the differences that come out of our diversity are indeed a source of strength demonstrated by the rich insights that came out of the conference,” said Nyamunda who is also an employee of the UFS Department of Human Resources. 

Producing practical solutions
The three-tiered workshop aimed to bring change to campuses across the world, in communities and beyond. This was the third workshop in the series which has taken place in India and the UK. The outcomes will directly feed into the 2020 Commonwealth Youth Forum to be held in Kigali, Rwanda later this year.

The group of students worked together to develop tangible solutions that address shared global issues such as gender-based violence, climate change and inequality. Joining the young leaders were expert speakers and organisations including the International Centre of Nonviolence, the Gandhi Development Trust, as well as the Commonwealth Countering Violent Extremism (CVE) Unit.

Global solutions for global problems
The Commonwealth states that with more than 60% of the Commonwealth’s 2.4 billion people younger than 30, the voices of young people have never been more important. Students across the globe are setting new agendas for social debates, challenging communities and governments to listen and work with young people to develop solutions to these intersecting issues and bring about real change.

In joining forces with other young thought leaders from around the world, Nyamunda drew on his experience as an International Students Association Founder and first President, the former 2017 Student Representative Council (SRC) member for International Students, and the Vice-Chairperson of the South African Board for People Practices: UFS Chapter. 

As one of the 40 delegates from across the globe, Nyamunda was given a sense of hope after he witnessed how keen young people are to build a better future. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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