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24 August 2020 | Story Amanda Tongha | Photo Supplied
Keitumetse Betsy Eister says the information they provide is used by researchers “in conducting much-needed research aimed at contributing towards the knowledge base of South Africa, knowledge aimed at building our nation towards a developed country”.

The role of Keitumetse Betsy Eister, Director: Library and Information Services – who leads a diverse team of 65 staff members – is to ensure that the University of the Free State community has access to information. This is done to “support lecturers in teaching researched content to undergraduate and postgraduate students and to assist students in their learning expedition by supporting them towards academic success and life-long learning”. Giving an overview of the role of the UFS Library and Information Services, Eister adds that the information they provide is used by researchers “in conducting much-needed research aimed at contributing towards the knowledge base of South Africa, knowledge aimed at building our nation towards a developed country”. This information is also beneficial to support staff and the management of the university, who are using it to deliver well-researched services.

With a masters’ degree in Library and Information Services and working on her PhD, Eister is the right person to ensure that the right information gets to the right people. A mother of two and someone that colleagues look up to, there is much to learn about this UFS champion woman. 


Tell us about yourself

I was born and bred in Thaba Nchu 56 years ago. I remain grateful and proud of the type of parents I had, who instilled in me the belief and love for education, a foundation that has grounded me and led me to where I am today. 

I believe in the teachings of the late Steven Covey, one of which is “the main thing is to keep the main thing the main thing”. In short, he says you need to stay focused on what you choose to do. In staying focused, I prefer to be driven by principles that have proven to have worked well in humanity, such as the government’s batho pele principles, ubuntu principles, ethical leadership principles, and so on.
 
On being a UFS staff member
 
I am proud of the 10 years I have spent as a Kovsie, with staff members who always remind me about the positive contributions I have made in their lives. Many of them have worked on their qualifications, some have obtained their first degrees, while others have improved their qualifications. At this stage, I can safely say the UFS LIS is a learning organisation, with four of us busy with doctoral studies, four with master’s studies, three with their honours, and six with their first degrees. We have also been working on our research capabilities, with two articles already published. 
 
Advice to her 15-year-old self

Looking back, I see a little girl who fortunately made the right choices in life. The most important one was to listen to my parents. I went to a girls’ high school, the St Anne’s High School. At one stage, we performed the Bible story, Joseph and the Amazing Technicolour Dreamcoat, and I played the role of one of Pharaoh’s dancers. I developed a love for dancing and wanted to turn it into a career. My parents advised me to get my education first; I wasn’t very pleased with that, but I listened to them. I am glad that this 15-year-old worked on her education; I believe I would never have been the self-actualised woman I am today, given the dancing-career opportunities that were scarce for black people during those years. I believe education is key, whether you want to work as an employee or run your own business. It brings with it the maturity and knowledge required in both areas of productivity.  
 
Women who inspires her

Prof Mamokgethi Phakeng, the UCT Vice-Chancellor. She is a classic example of what it means to spend the 24 hours we all have in a day; what you do with it depends on you. I see her using it to make an impact on a number of fronts within her circles of life, showing what ‘woman power’ is capable of. UCT students call her ‘Deputy Mother’, hooking up with them on social media. I, for example, join her every Sunday at 16:00 during her one-hour sessions, taking us through all aspects of postgraduate studies; this is for anyone to join, not only UCT students. She has now started sessions on building a career in academia. She seems to be living a balanced life, also making time for exercising and hiking.

 


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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