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18 August 2020 | Story Eugene Seegers | Photo Sonia du Toit/Kaleidoscope Studios
Dr Marinkie Madiope looks up to her mother as an inspirational woman.

Dr Maria ‘Marinkie’ Madiope is not your average professional woman. Her academic record speaks of vigilant style and resilient independence. The challenge of discovery, innovation, and stretching herself and everyone around her are qualities she values. The University of the Free State benefits from the extraordinary energy that characterises this woman. She is an infectious team leader, spurring others on to ever-greater heights, and is always on the lookout for something she can do for others: whether it is large-scale advocacy for women or smaller acts of empowerment. She describes herself as an “ever-present mother and sister” to those with whom she works. It is humbling to watch her Ubuntu in action. 

Please tell us about yourself

“My academic interests lie in the realm of ICT and curriculum design and development, which is what drew me to working on the South Campus. Open, Distance, and eLearning (ODeL) is also close to my heart, and I have been the editor of Progressio, the only ODeL journal in South Africa, since 2016.

My expertise in eLearning is another of my strengths; I designed the Unisa online ethics course, which was launched in Geneva in 2015 and is currently being offered internationally in collaboration with Ethics SA. 

As part of community engagement, I take part in the Africa Crèche Project to empower women. I enjoy working with young minds and little humans to provide them opportunities to which they otherwise would not have access.”

What do you do at the university?

“I am currently the Principal of the South Campus in Bloemfontein. The South Campus is dedicated to delivering quality distance education to sectors of society that would not necessarily have access to higher education. It advances education through ODeL delivery modes.

 

It is … vital to avoid dwelling on past mistakes, because regret robs you of joy. - Dr Maria Madiope, Principal: UFS South Campus.


“I enjoy the opportunity to transform the Open Distance Learning campus of the UFS to a digitised university.  I cannot express the feelings I have when welcoming students to the UFS to unlock their future, or when they graduate. Especially students who have gone through very traumatic home, personal, or academic times. They still succeed, even when others have given up on them.”

What advice would you give to a 15-year-old you?

“I see women as proud warriors — resilient and strong guardians of the future generations. I would encourage a 15-year-old me to be enthusiastic, confident, and authentic. It is also vital to avoid dwelling on past mistakes, because regret robs you of joy. The best decision I ever made was embracing Education and making sure that I was not only certified but learned to empower others in a humble way.” 

Is there a woman who inspires you and who you would like to celebrate this Women’s Month, and why?

“Although I am also inspired by Maya Angelou’s poem Still I rise, my mother is my biggest inspiration. She always had a smile on her face no matter how hard she worked, and she loved everyone. Her greatest strength is her ability to let nothing and no one remove her crown: ‘Strong winds may blow, but a QUEEN will bobby pin that thang in place and persevere because she is more than a conqueror’.”

“I am also inspired by the united force of women from all walks of life who, through a mass demonstration, marched to the Union Buildings in Pretoria on 9 August 1956, protesting against the unjust pass laws enforced on women in South Africa. This is in line with the 2020 Women's History Month theme, Valiant Women of the Vote. The theme honours the brave women who fought to win suffrage rights for women, and for the women who continue to fight for the voting rights of others. I SALUTE ALL WOMEN!

Wathint' Abafazi, Wathint' Imbokodo / You Strike A Woman, You Strike A Rock!!!!

 

 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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