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24 August 2020 | Story Thabo Kessah | Photo Supplied
Lebohang Masoabi believes she is a champion woman as she commits her time to nurture other champions.

Growing up with an inferiority complex has taught Lebohang Masoabi to flourish in her adult life. She credits former Vice-Chairperson of the University of the Free State’s Council, Dr Nthabeleng Rammile, as a woman who continues to inspire her. She recently won an Innovation in Learning and Teaching award during the Qwaqwa Campus Centre for Teaching and Learning’s Excellence in Learning and Teaching Awards. 

She has just completed her MCom degree in Business Management, focusing on the role of entrepreneurial education on attitudes and intentions of university students. 

Please tell us about yourself: Who you are and what you do? 

My name is Lebohang Masoabi. I am a Lecturer in the Department of Business Management at the University of the Free State Qwaqwa Campus. My areas of expertise include, but are not limited to, entrepreneurship and marketing.

Is there a woman who inspires you and who you would like to celebrate this Women’s Month, and why?

Dr Nthabeleng Rammile. She is intentional and unapologetic about pursuing her destiny. She is a great example of defying limitations. She constantly challenges her abilities. She oozes confidence. But above all, I love how she is passionate about the growth and development of other women, and how she has made it her life’s work to ensure that other women succeed in pursuit of their dreams. 

What are some of the challenges you’ve faced in your life that have made you a better woman?

Self-esteem issues: I had to learn to love myself and believe in myself and when I overcame that, I was unstoppable.

Inferiority complex: I was always afraid to express my full potential, wondering if I am worth it compared to others in my professional and personal space. I then realised that I am not weak, I am not vulnerable, I am not a damsel in distress. The day I realised my full potential as a woman, I flourished.

 

I had to learn to love myself and believe in myself and when I overcame that, I was unstoppable.

What advice would you give to the 15-year-old you?

• You are worth more than you think.
• Not everyone is going to like you, and that is fine.
• Be brave and do what scares you.
• Be kind to yourself.
• Forgive quickly, move on quickly.
• The girls who did not like you then, want to be you now!
• Learn to breathe through the tough moments, it’s not the end of the world.

What would you say makes you a champion woman [of the UFS]?

For the past four years on our campus, I have committed my time and energy to mentor students who are in quest of their professional and personal development, some of whom have launched their careers and have become champions in their own spaces.

So, my answer to this question is that what makes me a champion woman of the UFS is the fact that I nurture other champions!

 


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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