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25 August 2020 | Story Andre Damons | Photo Pierce van Heerden
Prof Felicity Burt is a passionate virologist with more than 25 years of research on medically significant viruses that cycle in nature and are transmitted to humans via mosquitoes, ticks, or animals.

Prof Felicity Burt, an expert in arbovirology in the Division of Virology, has been leading the University of the Free State (UFS) COVID-19 Task Team over the past five months. Prof Burt is a passionate virologist with more than 25 years of research on medically significant viruses that cycle in nature and are transmitted to humans via mosquitoes, ticks, or animals.

As the UFS is celebrating its champion women this Women’s Month, Prof Burt gives us some insight into who she is. 

Please tell us about yourself

I am an arbovirologist from the Division of Virology in the Faculty of Health Sciences, and the National Health Laboratory Service. Who am I? I am a mum, a wife, a daughter, a sister, a sister-in-law, a friend, a scientist, a colleague, a professor.  I am passionate about my work and have spent more than 25 years researching medically significant viruses that cycle in nature and are transmitted to humans via mosquitoes, ticks, or animals. 
My research group investigates the various mechanisms that viruses use to cause disease, and I am particularly interested in how our bodies respond to infection that can help us develop vaccines or therapies. Raising awareness of these viruses, profiling disease associated with different viruses, and developing tools for surveillance programmes all contribute towards understanding pathogens and the public-health implications. I am so grateful for the opportunities my career has provided me, which includes travelling all over the world for conferences and meetings and participating in outbreak responses in Africa.   
   
Is there a woman who inspires you and who you would like to celebrate this Women’s Month, and why?

I am inspired by all women who set goals and work to achieve them. The goals may vary, but they are important and challenging to each individual.  Hence, I would like us to acknowledge and celebrate all women who achieve their goals through hard work, dedication, and of course, plenty of passion. 

What are some of the challenges you’ve faced in your life that have made you a better woman?

I have always been quite a shy person and still find it challenging to stand up in front of an audience. I was born in Zimbabwe and when I finished school, I moved to South Africa to study at the University of the Witwatersrand. Moving on my own to Johannesburg at the age of 18 was definitely a challenge for a quiet, reserved girl from Harare. Compared to home, Johannesburg was a mammoth city; however, I absolutely loved university life, met people who became lifelong friends, and pursued a career in science. I try to learn from my many mistakes and treat others how I would like to be treated, especially with kindness. 

What advice would you give to the 15-year-old you?

Dream on girl, and it doesn’t matter if they don’t all come true; life isn’t going to turn out as expected, but as long as you enjoy the journey. You don’t have to be the best, but you have to do your best – with passion of course. 

What would you say makes you a champion woman [of the UFS]?

To be honest, I wouldn’t call myself a champion, but I am quite proud of what I have established at the UFS. With hard work and passion, contributions from colleagues, support from management, and never forgetting a whole bunch of wonderfully enthusiastic students, we have built an active postgraduate research group, graduated multiple students, published scientific articles in international journals, presented our research at conferences, contributed to community engagement, had fun, and still have plenty more to achieve!  

 

News Archive

New world-class Chemistry facilities at UFS
2011-11-22

 

A world-class research centre was introduced on Friday 18 November 2011 when the new Chemistry building on the Bloemfontein Campus of the University of the Free State (UFS) was officially opened.
The upgrading of the building, which has taken place over a period of five years, is the UFS’s largest single financial investment in a long time. The building itself has been renovated at a cost of R60 million and, together with the new equipment acquired, the total investment exceeds R110 million. The university has provided the major part of this, with valuable contributions from Sasol and the South African Research Foundation (NRF), which each contributed more than R20 million for different facets and projects.
The senior management of Sasol, NECSA (The South African Nuclear Energy Corporation), PETLabs Pharmaceuticals, and visitors from Sweden attended the opening.

Prof. Andreas Roodt, Head of the Department of Chemistry, states the department’s specialist research areas includes X-ray crystallography, electrochemistry, synthesis of new molecules, the development of new methods to determine rare elements, water purification, as well as the measurement of energy and temperatures responsible for phase changes in molecules, the development of agents to detect cancer and other defects in the body, and many more.

“We have top expertise in various fields, with some of the best equipment and currently competing with the best laboratories in the world. We have collaborative agreements with more than twenty national and international chemistry research groups of note.

“Currently we are providing inputs about technical aspects of the acid mine water in Johannesburg and vicinity, as well as the fracking in the Karoo in order to release shale gas.”

New equipment installed during the upgrading action comprises:

  • X-ray diffractometers (R5 million) for crystal research. Crystals with unknown compounds are researched on an X-ray diffractometer, which determines the distances in angstroms (1 angstrom is a ten-billionth of a metre) and corners between atoms, as well as the arrangement of the atoms in the crystal, and the precise composition of the molecules in the crystal.
  • Differential scanning calorimeter (DSC) for thermographic analyses (R4 million). Heat transfer and the accompanying changes, as in volcanoes, and catalytic reactions for new motor petrol are researched. Temperature changes, coupled with the phase switchover of fluid crystals (liquid crystals -watches, TV screens) of solid matter to fluids, are measured.
  • Nuclear-magnetic resonance (NMR: Bruker 600 MHz; R12 million, one of the most advanced systems in Africa). A NMR apparatus is closely linked with the apparatus for magnetic resonance imaging, which is commonly used in hospitals. NMR is also used to determine the structure of unknown compounds, as well as the purity of the sample. Important structural characteristics of molecules can also be identified, which is extremely important if this molecule is to be used as medication, as well as to predict any possible side effects of it.
  • High-performance Computing Centre (HPC, R5 million). The UFS’ HPC consists of approximately 900 computer cores (equal to 900 ordinary personal computers) encapsulated in one compact system handling calculations at a billion-datapoint level It is used to calculate the geometry and spatial arrangements, energy and characteristics of molecules. The bigger the molecule that is worked with, the more powerful the computers must be doing the calculations. Computing chemistry is particularly useful to calculate molecular characteristics in the absence of X-ray crystallographic or other structural information. Some reactions are so quick that the intermediary products cannot be characterised and computing chemistry is of invaluable value in that case.
  • Catalytic and high-pressure equipment (R6 million; some of the most advanced equipment in the world). The pressures reached (in comparison with those in car tyres) are in gases (100 times bigger) and in fluids (1 500 times) in order to study very special reactions. The research is undertaken, some of which are in collaboration with Sasol, to develop new petrol and petrol additives and add value to local chemicals.
  • Reaction speed equipment (Kinetics: R5 million; some of the most advanced equipment in the world). The tempo and reactions can be studied in the ultraviolet, visible and infrared area at millisecond level; if combined with the NMR, up to a microsecond level (one millionth of a second.

Typical reactions are, for example, the human respiratory system, the absorption of agents in the brain, decomposition of nanomaterials and protein, acid and basis polymerisation reactions (shaping of water-bottle plastic) and many more.

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