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25 August 2020 | Story Andre Damons | Photo Pierce van Heerden
Prof Felicity Burt is a passionate virologist with more than 25 years of research on medically significant viruses that cycle in nature and are transmitted to humans via mosquitoes, ticks, or animals.

Prof Felicity Burt, an expert in arbovirology in the Division of Virology, has been leading the University of the Free State (UFS) COVID-19 Task Team over the past five months. Prof Burt is a passionate virologist with more than 25 years of research on medically significant viruses that cycle in nature and are transmitted to humans via mosquitoes, ticks, or animals.

As the UFS is celebrating its champion women this Women’s Month, Prof Burt gives us some insight into who she is. 

Please tell us about yourself

I am an arbovirologist from the Division of Virology in the Faculty of Health Sciences, and the National Health Laboratory Service. Who am I? I am a mum, a wife, a daughter, a sister, a sister-in-law, a friend, a scientist, a colleague, a professor.  I am passionate about my work and have spent more than 25 years researching medically significant viruses that cycle in nature and are transmitted to humans via mosquitoes, ticks, or animals. 
My research group investigates the various mechanisms that viruses use to cause disease, and I am particularly interested in how our bodies respond to infection that can help us develop vaccines or therapies. Raising awareness of these viruses, profiling disease associated with different viruses, and developing tools for surveillance programmes all contribute towards understanding pathogens and the public-health implications. I am so grateful for the opportunities my career has provided me, which includes travelling all over the world for conferences and meetings and participating in outbreak responses in Africa.   
   
Is there a woman who inspires you and who you would like to celebrate this Women’s Month, and why?

I am inspired by all women who set goals and work to achieve them. The goals may vary, but they are important and challenging to each individual.  Hence, I would like us to acknowledge and celebrate all women who achieve their goals through hard work, dedication, and of course, plenty of passion. 

What are some of the challenges you’ve faced in your life that have made you a better woman?

I have always been quite a shy person and still find it challenging to stand up in front of an audience. I was born in Zimbabwe and when I finished school, I moved to South Africa to study at the University of the Witwatersrand. Moving on my own to Johannesburg at the age of 18 was definitely a challenge for a quiet, reserved girl from Harare. Compared to home, Johannesburg was a mammoth city; however, I absolutely loved university life, met people who became lifelong friends, and pursued a career in science. I try to learn from my many mistakes and treat others how I would like to be treated, especially with kindness. 

What advice would you give to the 15-year-old you?

Dream on girl, and it doesn’t matter if they don’t all come true; life isn’t going to turn out as expected, but as long as you enjoy the journey. You don’t have to be the best, but you have to do your best – with passion of course. 

What would you say makes you a champion woman [of the UFS]?

To be honest, I wouldn’t call myself a champion, but I am quite proud of what I have established at the UFS. With hard work and passion, contributions from colleagues, support from management, and never forgetting a whole bunch of wonderfully enthusiastic students, we have built an active postgraduate research group, graduated multiple students, published scientific articles in international journals, presented our research at conferences, contributed to community engagement, had fun, and still have plenty more to achieve!  

 

News Archive

Champagne and cancer have more in common than you might think
2013-05-08

 

Photo: Supplied
08 May 2013

No, a glass of champagne will not cure cancer....

…But they have more in common than you might think.

Researchers from the Departments of Microbial Biochemical and Food Biotechnology, Physics and the Centre for Microscopy at the University of the Free State in South Africa were recently exploring the properties of yeast cells in wine and food to find out more of how yeast was able to manufacture the gas that caused bread to rise, champagne to fizz and traditional beer to foam. And the discovery they made is a breakthrough that may have enormous implications for the treatment of diseases in humans.

The team discovered that they could slice open cells with argon gas particles, and look inside. They were surprised to find a maze of tiny passages like gas chambers that allowed each cell to ‘breathe.’ It is this tiny set of ‘lungs’ that puts the bubbles in your bubbly and the bounce in your bread.

But it was the technique that the researchers used to open up the cells that caught the attention of the scientists at the Mayo Clinic (Tumor Angiogenesis and Vascular Biology Research Centre) in the US.

Using this technology, they ultimately aim to peer inside cells taken from a cancer patient to see how treatment was progressing. In this way they would be able to assist the Mayo team to target treatments more effectively, reduce dosages in order to make treatment gentler on the patient, and have an accurate view of how the cancer was being eliminated.

“Yes, we are working with the Mayo Clinic,” said Profes Lodewyk Kock from the Microbial, Biochemical and Food Biotechnology Department at the UFS.

“This technique we developed has enormous potential for cell research, whether it is for cancer treatment or any other investigation into the working of cells. Through nanotechnology, and our own invention called Auger-architectomics, we are able to see where no-one has been able to see before.”

The team of Prof Kock including Dr Chantel Swart, Kumisho Dithebe, Prof Hendrik Swart (Physics, UFS) and Prof Pieter van Wyk (Centre for Microscopy, UFS) unlocked the ‘missing link’ that explains the existence of bubbles inside yeasts, and incidentally have created a possible technique for tracking drug and chemotherapy treatment in human cells.

Their work has been published recently in FEMS Yeast Research, the leading international journal on yeast research. In addition, their discovery has been selected for display on the cover page of all 2013 issues of this journal.

One can most certainly raise a glass of champagne to celebrate that!

There are links for video lectures on the technique used and findings on the Internet at:

1. http://vimeo.com/63643628 (Comic version for school kids)

2. http://vimeo.com/61521401 (Detailed version for fellow scientists)

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