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28 December 2020 | Story André Damons | Photo Supplied
Dr Michael Pienaar is a lecturer in the University of the Free State’s (UFS) department of Paediatrics and Child Health.

A lecturer from the University of the Free State’s (UFS) department of Paediatrics and Child Health is investigating the use of artificial neural networks to develop models for the prediction of patient outcomes in children with severe illness.

Dr Michael Pienaar, senior lecturer and specialist, is conducting this research as part of his doctoral research and the study deals primarily with the development of models that are designed and calibrated for use in South Africa. These artificial neural networks are computer programs designed to mimic some of the learning characteristics of biological neurons.

The potential applications of models

According to Dr Pienaar these models have traditionally been developed in high-income nations using conventional statistical methods.

“The potential applications of such models in the clinical setting include triage, medical research, guidance of resource allocation and quality control. Having initially begun this research investigating the prediction of mortality outcomes in the paediatric intensive care unit (PICU) I have broadened my scope to patients outside of PICU, seeking to identify children early during their illnesses who are at risk of serious illness requiring PICU,” says Dr Pienaar.

The research up until now has been directed towards the identification of characteristics that are both unique to children with serious illness in South Africa, but also accessible to clinicians in settings where expertise and technical resources are limited.

Research still in the early changes

The research is still in its early stages but next year a series of expert review panels will be held to investigate the selection of variables for the model, after which the collection of clinical data will begin. Once the data has been collected and prepared, a number of candidate models will be developed and evaluated. This should be concluded by the end of 2022.

Says Dr Pienaar: “The need to engage with the rapid proliferation of technology, particularly in the realms of machine learning, mobile technology, automation and the Internet of Things is as great in medical research now as it is in any academic discipline.

“It is critical that research, particularly in South Africa, engage with this in order to take advantage of the opportunities offered and avoid the dangers that go paired with them. Together with the technology as such, it has been essential to pursue this project as an interdisciplinary undertaking involving clinicians, biostatisticians and computer engineers.”

Hope for the research  

Dr Pienaar says he was very fortunate and grateful to be the recipient of a generous interdisciplinary grant from the UFS which has allowed him to procure software and equipment that is critical to this project.

“The hope for this research is that the best performing of these models can be integrated with a mobile application that assists practitioners in a wide range of settings in the identification, treatment and early referral of children at high risk of severe illness. I would like to expand this research project to include other countries in Africa and South America and to use it as a bridge to collaboration with other clinical researchers in the Global South,” says Dr Pienaar.

As an early career researcher, Dr Pienaar hopes that this research can serve as a platform to build a body of research that uses the rapid technological advances of these times together with a wide range of collaborations with other disciplines in the pursuit of better child health.

He concludes by saying that he has had excellent support thus far from his supervisors, Prof Stephen Brown (Faculty of Health Sciences, UFS), Dr Nicolaas Luwes (Faculty of Computer Science and Engineering, Central University of Technology) and Dr Elizabeth George (Medical Research Council Clinical Trials Unit, University College London). I have also been supported by the Robert Frater Institute in the Faculty of Health Sciences.

News Archive

Shimlas now second on Varsity Cup log
2015-02-25

After scoring nine tries to none to establish a 57-0 win over the Central University of Technology’s (CUT) Ixias in round three of the 2015 Varsity Cup Rugby Tournament, the UFS Shimlas are now second on the overall log.

Despite thunder showers in Bloemfontein on the evening of Monday 23 February, the match at the CUT Rugby Stadium continued. Shimlas’ Arthur Williams opened the scoreboard early with the first try of the evening, after getting his hands on a loose ball to break through the CUT defense line. Only four minutes later, Shimlas’ flank Gerhard Olivier scored another try. Both of these tries were successfully converted by Niel Marais, putting Shimlas in a 16-0 lead within less than seven minutes.

By halftime, the Shimlas’ lead had increased to 39-0. Daniel Maartens started the second-half scoring for the UFS when he crossed the try line in the 46th minute to secure Shimlas’ seventh try. After another successful conversion kick by Marais, the scoreboard read 47-0.

The match began to lose its spark as handling errors and ill-discipline became the order of the day. CUT were reduced to 14 men for the second time in the match, when Boetie Makethlo was sent to the sin bin in the 75th minute for an infringement at the breakdown, inches away from his try line.

Maartens went over the try line again in the 78th minute, scoring Shimlas’ eighth try in the match and taking his team’s score beyond the 50 mark. Shimlas managed yet another try in the last minute, with Niell Jordaan diving over the try line for old time’s sake.

Although the Shimlas’ 2015 Varsity Cup started off with a 29-29 draw against the University of Pretoria’s Tuks in Bloemfontein, they returned the following week to clinch a 24-0 win against the University of Johannesburg at the UJ Stadium. Apart from Tuks, who is at this stage on top of the log, no team has scored against Shimlas thus far in the 2015 Varsity Cup.

Up next, Shimlas will face the Stellenbosch University’s Maties side at Shimla Park in Bloemfontein for round four of the tournament on Monday 2 March 2015.

Our Player that Rocks: Niell Jordaan

Shimlas’ point scorers:

Tries: Arthur Williams, Gerhard Olivier (2), Marco Klopper, Vuyani Maqina (2), Daniel Maartens (2), Niell Jordaan
Conversion kicks: Niel Marais 4

 

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