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28 December 2020 | Story André Damons | Photo Supplied
Dr Michael Pienaar is a lecturer in the University of the Free State’s (UFS) department of Paediatrics and Child Health.

A lecturer from the University of the Free State’s (UFS) department of Paediatrics and Child Health is investigating the use of artificial neural networks to develop models for the prediction of patient outcomes in children with severe illness.

Dr Michael Pienaar, senior lecturer and specialist, is conducting this research as part of his doctoral research and the study deals primarily with the development of models that are designed and calibrated for use in South Africa. These artificial neural networks are computer programs designed to mimic some of the learning characteristics of biological neurons.

The potential applications of models

According to Dr Pienaar these models have traditionally been developed in high-income nations using conventional statistical methods.

“The potential applications of such models in the clinical setting include triage, medical research, guidance of resource allocation and quality control. Having initially begun this research investigating the prediction of mortality outcomes in the paediatric intensive care unit (PICU) I have broadened my scope to patients outside of PICU, seeking to identify children early during their illnesses who are at risk of serious illness requiring PICU,” says Dr Pienaar.

The research up until now has been directed towards the identification of characteristics that are both unique to children with serious illness in South Africa, but also accessible to clinicians in settings where expertise and technical resources are limited.

Research still in the early changes

The research is still in its early stages but next year a series of expert review panels will be held to investigate the selection of variables for the model, after which the collection of clinical data will begin. Once the data has been collected and prepared, a number of candidate models will be developed and evaluated. This should be concluded by the end of 2022.

Says Dr Pienaar: “The need to engage with the rapid proliferation of technology, particularly in the realms of machine learning, mobile technology, automation and the Internet of Things is as great in medical research now as it is in any academic discipline.

“It is critical that research, particularly in South Africa, engage with this in order to take advantage of the opportunities offered and avoid the dangers that go paired with them. Together with the technology as such, it has been essential to pursue this project as an interdisciplinary undertaking involving clinicians, biostatisticians and computer engineers.”

Hope for the research  

Dr Pienaar says he was very fortunate and grateful to be the recipient of a generous interdisciplinary grant from the UFS which has allowed him to procure software and equipment that is critical to this project.

“The hope for this research is that the best performing of these models can be integrated with a mobile application that assists practitioners in a wide range of settings in the identification, treatment and early referral of children at high risk of severe illness. I would like to expand this research project to include other countries in Africa and South America and to use it as a bridge to collaboration with other clinical researchers in the Global South,” says Dr Pienaar.

As an early career researcher, Dr Pienaar hopes that this research can serve as a platform to build a body of research that uses the rapid technological advances of these times together with a wide range of collaborations with other disciplines in the pursuit of better child health.

He concludes by saying that he has had excellent support thus far from his supervisors, Prof Stephen Brown (Faculty of Health Sciences, UFS), Dr Nicolaas Luwes (Faculty of Computer Science and Engineering, Central University of Technology) and Dr Elizabeth George (Medical Research Council Clinical Trials Unit, University College London). I have also been supported by the Robert Frater Institute in the Faculty of Health Sciences.

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Plant-strengthening agent enhances natural ability of plants to survive
2015-07-27

Drought, diseases, and fungi. These are factors that farmers have no control over, and they often have to watch despondently as their crops are damaged. In addition, the practice of breeding plants in special and strictly-controlled conditions, has resulted in crops losing the chemical ability to protect themselves in nature.

Researchers in the Department of Soil, Crop, and Climate Sciences at the University of the Free State (UFS) have developed an organic agent that restores this chemical imbalance in plants. It enables the plant to build its own resistance against mild stress factors, and thus ensures increased growth and yield by the plant.

ComCat®, a plant-strengthening agent, is the result of extensive research by the German company, Agraforum AG, together with the UFS. Commercialisation was initially limited to Europe, while research was done at the UFS.

“Plants have become weak because they were grown specially and in isolation. They can’t protect themselves any longer,” says Dr Elmarie van der Watt from the department.

Dr Van der Watt says that, in nature, plants communicate by means of natural chemicals as part of their resistance mechanisms towards various stress conditions. These chemicals enable them to protect themselves against stress conditions, such as diseases and fungi (biotic conditions) or wind and droughts (abiotic conditions).

Most wild plant varieties are usually well-adapted to resist these stress factors. However, monoculture crops have lost this ability to a large extent.

The European researchers extracted these self-protection chemicals from wild plants, and made them available to the UFS for research and development.

“This important survival mechanism became dormant in monoculture crops. ComCat® wakes the plant up and says ‘Hey, you should start protecting yourself’.”

Research over the last few years has shown that the agent, applied mostly as a foliar spray, subsequently leads to better seedlings, as well as to growth, and yields enhancement of various crops. This is good news for the agricultural sector as it does not induce unwanted early vegetative growth that could jeopardise the final yield ? as happened in the past for nitrogen application at an early growth stage.

“The use of synthetic agents, such as fungicides which contain copper, are now banned. Nowadays, options for natural and organic agriculture is being investigated. This product is already widely used in Europe, but because farmers are often swamped by quacks, the South African market is still somewhat sceptical.”

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