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09 December 2020 | Story Carli Kleynhans | Photo Supplied
Carli Kleynhans.

With the most gruelling year recorded in our entire lives, gradually coming to an end we remain hopeful and thankful that we have made it through. From the unexpected shock of going into lockdown, to the worry of having to use a blended approach to succeed in your academics and now finally settling into a new normal, we at the advising office bestow upon you the title of Kovsie champion…because that's exactly what you are!

One of our many champions, Carli Kleynhans, a 3rd (final) year student enrolled for BA Psychology and English shares how she survived…no, actually how she has thrived in 2020. 

• What was your biggest concern about your academics when you found out the country was going into lockdown?

My biggest concern about my academics as a final year student was whether the online learning and tests would provide the same in depth learning experiences that are necessary to build upon for future studies.

• What are some of the challenges you've experienced along the way?

Staying focused and trying not to procrastinate was a big challenge I had to conquer, especially trying to not be distracted by my family and my phone. How I survived and was able to thrive in 2020!

• What are some of the strategies you've used to ensure your academics don’t suffer? 

Time management was one of the most important strategies that I applied. For most of my classes, I was able to focus each week on a different module, by working and studying in advance I was able to keep up with my workload and still have the weekends to focus on myself, therefore creating designated time to work, study and also time to relax and read. 

• What support have you received from the institution that's helped you thus far? 
Most of my lecturers have provided needed support regarding our academics. The institution helped provide clarity with everything that was going on. 

• What do you think the UFS could have done differently to support student success? 
I think the UFS could have provided more resources for the final year students, especially considering we have to apply for further studies; online it was difficult to discern exactly what was necessary for the applications, whereas in class I feel more information would have been provided. 

• What has kept you motivated? 

Knowing it is my final year has helped to motivate me, as I have to use these grades to apply for further studies. I recently received recognition from Golden Key and this helped to further inspire me to work even harder at my academics.

• What advice do you have for your fellow Kovsies who are finding it difficult to keep going? 
Remember to make time for yourself, to look after yourself and your mental health, especially in these difficult times. Work in advance and keep to your personal academic calendar.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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