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21 December 2020 | Story André Damons | Photo Supplied
The KAT Walk mini (Omni Directional Treadmill) used to reduce and eliminate cybersickness.

An officer at the School of Nursing Simulation Laboratory of the University of the Free State (UFS) is aiming to cure or minimise cybersickness in nursing students with a popular virtual reality gaming tool.

Bennie Botha, who is acting as head of the Information, Communication and Simulation Technology at the School of Nursing Simulation Laboratory, developed a virtual environment in which nursing students use immersive virtual reality to perform a simulation scenario. This is part of his master’s degree in Computer Science and Informatics under the supervision of Dr Lizette de Wet and co-supervisor Prof Yvonne Botma.

Botha received his master’s degree with distinction during the UFS virtual graduation in October.

Cybersickness

Botha had found that some people experience cybersickness (almost like motion sickness), which is a significant issue and difficult to address. This he would now try to address with a virtual reality gaming tool – the KAT Walk mini.

According to Botha this technology has never been attempted for health-care education and is mostly used in military and pilot training and is very popular as a gaming platform for hardcore virtual reality gamers.

“To test and provide a possible solution I am going to incorporate the KAT Walk mini (Omni Directional Treadmill – almost like the Ready Player One concept) into which students are strapped and they can physically walk and turn around without the need for large open spaces.

“With this I will try and determine whether it decreases or even eliminates cybersickness due to sensory mismatch while using immersive virtual reality. I wanted to provide possible evidence of what causes cybersickness and want to enable virtual reality as an educational tool, not just for gaming. I think immersive virtual reality has a bright future if the kinks (of which the biggest is cybersickness) can be minimised,” says Botha.

Getting funding

He successfully applied for funding in 2020 and received R150 000.

“I must say I was surprised when I got the approval letter. I thought that due to the economic status it would not go through, but I was really glad when I got the approval as this is my dream and I love working with virtual reality for health care. The grant has made my dream come true, especially considering that this sounds more like something from science fiction,” says Botha.

The project started in November 2017 when Botha first conceptualised the idea and took it to Dr De Wet. He then started it as a masters’ project in 2018 and completed it at the end of 2019.

An equal opportunity for students

Botha says immersive virtual reality gives students more time and a more accessible platform where they can practise their skills as it is easy to use and easy to set up compared to other modalities of simulation. But the biggest task is developing a usable virtual environment that gives students more time to practise and increase their theory and practical integration which is key to providing highly skilled health-care professionals.

“By seeking and possibly implementing the new research, I aim to provide students an equal opportunity to partake in immersive virtual reality simulation as it currently excludes people who are prone to high levels of cybersickness. This means they cannot benefit from the same opportunities as other students do.

“I believe it can help all nursing students in SA and Africa as it is much more cost-effective than high-technology manikins and is easier to set up and access with much less manual input required to make it work (apart from the initial development.).”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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