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12 February 2020 | Story Rulanzen Martin | Photo Charl Devenish
Prof Francis Petersen
Prof Francis Petersen, UFS Rector and Vice-Chancellor opened the workshop on Monday, 10 February 2020.

Will an enclaved state work in a country like South Africa? How can universities produce graduates who will become engaged citizens, and what is the current status of the ANC and the DA? These were some of the key topics at a workshop on South Africa and Africa: Prevarication at the Precipice, hosted by the Department of Political Studies and Governance at the University of the Free State (UFS). 

The two-day workshop is an annual collaborative discussion platform between the UFS, chaired by Prof Hussein Solomon, the Southern African Centre for Collaboration on Peace and Security, and the Osaka School of International Public Policy

The workshop opened with Prof Francis Petersen, the UFS Rector and Vice-Chancellor who delivered his message from the perspective of higher education. 

He spoke about the importance of universities in South Africa being able to produce graduates who will become active citizens. 

Graduates should fulfill their role in society 

“Universities should be the place where we should educate and engage to let our students and graduates know what society should look like. If we don’t do that transformative thinking among our graduates we are going to perpetuate what society is,” Prof Petersen said. 

“I hope this conference won’t just debate the issues because we already know the answers. I hope this workshop will say what we need to do as active citizens to ensure that we start new building steps. International engagement is also important. As is our engagement with the continent.” 

Helen Zille on the State of South Africa 

Helen Zille, Chairperson of the DA Federal Council presented a talk on the State of South Africa in which she tabled three variables she believes can save the country from the precipice. “There should be three variables which can make a democracy work; a separate state (not a party-ruled state), the rule of law and a culture of accountability,” Zille said. 

Zille tabled the concept of an enclaved state a state which operates independently from party control. “There are increasingly isolated states in SA which are being pushed out of good governance and service delivery. An example of an enclave that functions well is the “justice enclave (Supreme Court of Appeal) in Bloemfontein”. 

She reiterated the importance of active citizenship. However she added that people who are active citizens are usually not the ones elected to office. 

Political Science workshop
The workshop brings together political scientists, academics, politicians and journalists who robustly discuss local
and international politics, economics and governance.  ( Photo: Charl Devenish) 


The role of active citizenship and the state of the country cannot be discussed in isolation from the state of the ruling ANC and the official opposition, the DA. Prof Dirk Kotze from the Department of Political Studies at Unisa, and Bonolo Selebano, Netwerk 24 political journalist, gave a glimpse into the status of Luthuli House (ANC headquarters in Johannesburg), and the DA. 

“ANC party politics are not unique. They are following a global trend. However, the credibility of the ANC is a big issue,” said Prof Kotze. In the political arena globally, political parties are redefining themselves and it is important for the ANC to figure out where it finds itself. Selebano wasn’t too optimistic about the DA either, saying the party should return to its liberation ideals. 


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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