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18 February 2020 | Story Nomonde Mbadi | Photo Charl Devenish
Star of Stars Gala evening
Attending the Star of Stars gala dinner, were from the left: Mar'c Scholtz, Chairperson of the Star of Stars competition; Prof Francis Petersen, Rector and Vice-Chancellor; Kamohelo Mphuthi, Star of Stars 2019/2020 winner; MEC for Treasury in the Free State, Mrs Gadija Brown; and Nomonde Mbadi, Director: Student Recruitment Services

An evening among the stars, celebrating some of the Free State’s brightest learners. This was the backdrop for the annual University of the Free State (UFS) Star of Stars competition gala dinner held on 1 February. The event, hosted by the Department of Student Recruitment Services, recognises Grade 12 learners from quintile 1, 2 and 3 schools in the province, especially those from rural communities. 

In its fourth year of existence, the Star of Stars competition rewards learners for academic performance, leadership achievement, and community involvement. The top-ten entries are selected through an adjudication process, with the winner verified by external evaluators. 

Recognising top matriculants in the Free State 

Recognised for his achievements in the 2019 National Senior Certificate (NSC) examinations, Kamohelo Mphuthi, a former learner from Leifo-Iziko Combined School in Reitz, walked away with the Star of Stars 2019/2020 title. Kamohelo is currently enrolled at Kovsies for a BSc degree majoring in Actuarial Science. In his acceptance speech, the Karee Residence student said, “In everything that you do, strive for nothing but perfection. I hope to be a leader who is an academic, who is affable and approachable, and a leader who inspires those who came before me as well as the future winners”. 

A new category was introduced for the first time – Sparkling Personality.  The finalists chose the one star that lit the room, was friendly with everyone, with a sparkling personality.  The winner was Bianca Mafukama from Tsebo Secondary School in Phuthaditjhaba.

Nomonde Mbadi, Director: Student Recruitment Services, said entries for the 2019/2020 competition were of an exceptionally high standard. “Five learners from the top-ten group were part of the provincial top-hundred learners in the past NSC examination.”  

Improving the lives of those living in rural communities

She said the competition is a unique recruitment initiative driven by the Department of Student Recruitment Services and supported by the Centre for Teaching and Learning, Kovsie Counselling, Student Affairs, and Mr Joe Serekoane from the Faculty of the Humanities, to guide and support learners through career counselling, mentorship, and adapting to campus life. 

Addressing the audience at the gala dinner, Prof Francis Petersen, Rector and Vice-Chancellor, encouraged the top-ten finalists to pursue their dreams with a relentless courage and an aspiration to succeed. Also in attendance, was the MEC for Treasury in the Free State, Mrs Gadija Brown, who complimented the University of the Free State as a partner in improving the lives of those living in rural communities.

All the finalists received bursaries from the Kovsie Alumni Trust and the University of the Free State, as well as gifts from the Fidelity Foundation, Bloempapier, and the Bloemfontein Business Chamber. Hill Mchardy and Herbst Attorneys awarded internships to two finalists enrolled for the LLB programme. To add dazzle and sparkle, Bridal Co and Euro Suit sponsored each finalist with formal attire. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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