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11 February 2020 | Story Valentino Ndaba | Photo Stephen Collett
UFS official opening
Kovsies is on track with the firm foundation laid in previous years. 2020 is a year where visibility and impact is the key theme.

WATCH: Official Opening 2020

Tackling 2020 with rigour and vigour is the top priority for the University of the Free State’s agenda and it’s all systems go after a year of building a solid foundation. Prof Francis Petersen, UFS Rector and Vice-Chancellor, addressed staff in his official Opening speech at the Bloemfontein Campus on Friday 7 February 2020.

“The university is on track with what it set out to deliver in 2019” Prof Petersen shared the successes of 2019 with the audience and outlined his vision and plans for 2020 with visibility and impact as the key themes. 

Prof Petersen urged staff to work hand-in-hand to ensure an outcome that generations will inherit with pride. “We have our eyes firmly set on the far horizon, to ensure that we bestow an institution on the next generation that is different from the past, a place where every essence is in perpetual renewal. That means every one of us is smaller than the institution, and every one of us needs to lay a brick that builds a university that is different from the past, more impressive than the past, an institution that will grow constantly.” 

Setting the pace

As a frame of reference, Prof Petersen pointed to engagement, conversation, clear communication and decisive action to yield the type of environment in which we all want to work and study. “I can assure you that we will continue with that engagement, in a sphere of respect, tolerance for different views by always focusing on what the Integrated Transformation Plan (ITP) stands for – which is fairness and social justice.”

Reflecting on the year that was.


Prof Petersen reflected on 2019 as a year which focused on a return on investment delivery as it relates to the Strategic Plan, ITP, seven Vice-Chancellor’s projects, institutional and multi-stakeholder group and institutional Risk Register. These guiding documents laid a firm foundation for implementation processes to take place this year.

Leading the way

The Rector related some success stories which include the increased number of NRF-rated researchers. “In the area of student success, we are probably leading the country and our inputs are globally known.”

As a national leader on the infrastructural and student accommodation front, the Department of Higher Education, Science and Technology often consults the UFS for advice on how other institutions can adequately spend their infrastructure grants. Moving forward, the university also plans to partner more with national and international institutions of higher learning with the aim of strengthening research and innovation ties.

On inclusiveness and social cohesion

Pressing issues such as gender-based violence and xenophobia are constantly being tackled by the Unit for Institutional Change and Social Justice in collaboration with other academic and support services. These parties have conducted and developed critical conversations, position papers, and policies to guide the institution towards an inclusive and socially cohesive space which embraces the values of ubuntu and respect.

In closing, Prof Petersen reminded the university community of the crucial role each individual plays in building a bright future. “We must always remember that the UFS exists through its staff and students and should never let one of them feel neglected or unheard.” 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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