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06 January 2020 | Story Igno van Niekerk | Photo Igno van Niekerk
Success is tied to the company you keep
Prof Brownhilder Neneh believes failure is part of success – it teaches you to be persistent and resilient.

As a young girl growing up in the Cameroon, her dad told her that once she had completed her first degree, she could choose where in the world she wanted to study. Her first choice was the United States; she applied and was admitted.

So, how did she come to complete her postgraduate studies and then became a professor and Head of the UFS Department of Business Management?


A matter of timing

Prof Brownhilder Neneh, Associate Professor in the Department of Business Management, tells the story. “It was a matter of timing. The new intake in the US took place in June; I started looking around and saw that there was an opportunity to come to the UFS. I did not want to waste six months; so, I came here, did my honours degree, and within one year and five months, I completed my master’s degree (Cum Laude), and then went home. I thought of doing my PhD in Germany but realised that the language might be a challenge; I came back and within a year and a few months, I completed my PhD.”

Listening to Prof Neneh relate the story, one might think she does nothing but study; although her academic workload is high, she finds the time to play with her 14-month-old baby every day. “When I arrive home and she sees me – that’s when my energy soars – and we start playing. Where possible, I take her to conferences with me. As a working mother, I understand the challenge of finding the balance, and my husband is great in supporting me.”


Finding the balance

Having risen to the position of professor, being happily married, and apparently having found the balance which many people seems to strive for their entire lives, I ask Prof Neneh what her recipe for success is. She doesn’t hesitate: “Success is tied to who you marry (if you get married), the company you keep, hard work, consistency, and always trying to be the best at what you do – and, oh yes, failure is part of success; it teaches you to be persistent and resilient. I also believe that God’s grace and favour has added to my success.” At a conference in September 2019, Prof Neneh once again talked about her favourite topic – women entrepreneurs and the challenges they face. She believes that there is a lot to be done to lessen the load of entrepreneurial women. And as I get ready to leave, I ask for her definition of success. She doesn’t hesitate: “Seeing students fly above you – and shining. Yes, to see them shine.”

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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