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31 July 2020 | Story Andre Damons | Photo Supplied
Prof Felicity Burt and Prof Paul Grobler from the UFS.

Three scientists from the University of the Free State (UFS), together with authors from other institutions, are part of an international COVID-19 study published in an international peer-reviewed scientific journal recently. 

Prof Paul Grobler, Academic Head of Department: Genetics; Prof Felicity Burt, researcher from the Division of Virology, Faculty of Health Sciences and the NHLS, and SARChI (South African Research Chairs Initiative) Research Chair in vector-borne and zoonotic diseases; as well as Prof Trudy Turner from the University of Wisconsin-Milwauwkee, but also an affiliated professor in the Department of Genetics at the UFS, are co-authors of the paper that appeared in Plos One. The study is titled: ACE2 and TMPRSS2 variation in savanna monkeys (Chlorocebus spp.): Potential risk for zoonotic/anthroponotic transmission of SARS-CoV-2 and a potential model for functional studies.

 The paper follows an initiative of Prof Chris Schmitt at Boston University with researchers affiliated to the University of California, Los Angeles, Rutgers University, the Polish Academy of Sciences, the Ministry of Health of the Russian Federation, the University of Antwerp, the Wake Forest School of Medicine, and the University of Wisconsin-Milwaukee. The team used the opportunity presented by previously sequenced genomes to screen for variation in the genes associated with susceptibility to infection with SARS-CoV-2.

Concerns about animal welfare and conservation issues

Prof Grobler, who has been studying vervet monkeys from a conservation perspective for two decades, says considering the impact of COVID-19 on the country, he feels that any aspect that might potentially help to understand the progression and transmission of the disease, as well as unexpected risks – however small – should be investigated. 
“Since wildlife management is my field, I am of course also concerned about the potential animal welfare and conservation issues involved.  It should, however, be emphasised that while SARS-CoV-2 infection in vervet monkeys has now been shown to be genetically possible, there is no proof of it actually happening in the wild yet.” 

“I am sure that much work on COVID-19 and vervets will follow internationally, but this is the first study to describe variation at the genes linked to susceptibility,” says Prof Grobler. 

Because of his previous work with vervet monkeys in South Africa and further afield, Prof Grobler was invited by Prof Schmitt to contribute to the manuscript.

“I made some suggestions from a conservation perspective, based on my interpretations and also recent international work that have shown that many primate species may be at risk for SARS-CoV-2 infection and are potentially vulnerable to COVID-19. I also felt that some aspects of the paper would be greatly improved with input from a South African expert in zoonotic disease to add to the genetic and conservation perspectives, and I therefore requested that Prof Burt also be approached.”

Potential for non-human primates infection

Prof Burt, whose research interests and expertise include the investigation of viruses of zoonotic origin, and/or those transmitted by mosquitoes and ticks that impact human and/or animal well-being – using a One Health approach – says the study was a collaborative effort between scientists with expertise in a wide range of disciplines, including biological anthropology, genetics, primatology, molecular biology, and virology.

“The concept of One Health encourages collaboration between multiple disciplines, promoting the concept that the interaction between humans, animals, and the environment has an impact on the health of people, animals, plants, and the environment. The outcome is an exciting study that incorporates knowledge from each discipline to investigate the potential susceptibility of non-human primate populations to SARS-CoV-2.” 

“The research suggests that there is potential for novel SARS-CoV-2 to infect non-human primates, and that surveillance of non-human primates living in close proximity to human populations is not only warranted, but is actually important for defining risk to both humans and animals,” says Prof Burt. 

According to her, the majority of recently emerged viruses, including SARS-CoV-2, were zoonotic in origin. The close proximity of humans and wild non-human primates provides potential for cross-species transmission of pathogens; for some endangered species, this could have devastating effects. Similarly, identifying if non-human primates have the potential to act as intermediate hosts for pathogens with significant public health implications, would be important for understanding zoonotic transmission.

“Novel viruses are continually emerging, and we need to be prepared. A multidisciplinary approach to understanding interactions at the wildlife-human interface will be essential for the prevention of future outbreaks.”

News Archive

New projects will enhance the infrastructure on our campuses
2011-02-04

 
Illustration:
The university's Main Gate in Nelson Mandela Avenue, as designed by The Roodt Partnership Architects.
 

A new entrance to the Main Campus, a high-performance centre, commercial gymnasium, rock-climbing wall, memorial garden for women and a botanical garden are but a few of the number of building and renovation projects that will take place at the Main Campus of the University of the Free State (UFS) in Bloemfontein. A number of projects are also being done on the Qwaqwa Campus.
On the Main Campus the entrance in Nelson Mandela Avenue is being adapted to match the university’s new corporative identity which was introduced last week. This project will be completed at the end of March 2011,
 
The creation of an environment conducive to the development of its students in the field of teaching, learning and research, as well as sports and culture is one of the main reasons why the UFS is renovating existing buildings and developing new infrastructure.
 
With the construction of a high-performance centre and commercial gymnasium, the university wants to create a work environment for its staff that will not only contribute to the cultivation of maximum work performance, but also to staff wellness. The centre with its foyer and administrative offices will furthermore consist of a health desk, university sports institute, sports sales, a spinning and aerobic centre, and dressing rooms. The total area will extend over 2114 m² and the construction will take approximately 18 months. This development will take place on the western side of the university’s Main Campus, directly opposite the Furstenburg Gate and next to the new student housing.
 
The UFS is also progressing well with other building projects which commenced last year. One of the projects is a new Education Building which is being constructed opposite the UFS Sasol Library. Upon completion this building will be used for the training of maths and science teachers in the Foundation Phase. It will include three classrooms for 100 students each and an auditorium for 225 students as well as an office block. The auditorium will also be used as a classroom. The building has been designed according to environmentally friendly principles to save water and use power effectively. It should be completed this year.
 
Planning for the construction of more student accommodation on the Main Campus as well as the Qwaqwa Campus is already well underway. On the Qwaqwa Campus, a residence with 200 beds is being constructed. This also includes a computer laboratory. According to the planning, this residence should be completed by the end of the first semester in 2011. Furthermore, four residences will be constructed on the Main Campus. These residences are in the planning phase.
 
In order to place technology within reach of Kovsie students and thereby empowering them, computer laboratories were installed at the respective residences. The computer laboratories will eventually make provision for approximately185 computers for student use. Proper security is also planned to safeguard the equipment.
 
Work to a new building for the Faculty of Health Sciences is also proceeding rapidly on the site where the vehicle pool and Hertz were previously used. This will include a lecture hall for 200 students, five venues for 100 students each, as well as offices. Students from the School for Medicine and Occupational Therapy will make use of these facilities.
 
The new building for the Faculty of Economic and Management Sciences between the Flippie Groenewoud Building and the Wynand Mouton Theatre is also coming along nicely.
 
On the university’s Qwaqwa Campus a new Education building is being constructed. This building will include a lecturing hall with 100 seats, four 50-seat classrooms, six offices, ablution facilities, a biology and science laboratory, as well as an information technology laboratory for 60 students.
 
In the meantime, existing buildings are being renovated on all the campuses. This includes, amongst others, improvements to the Architecture Building, the Biotechnology Building and the quarters for service workers on the Main Campus. Other improvements that have already been completed include the renovation of the Odeion’s foyer and the Callie Human Centre.
 
In future, students, staff and visitors to the UFS can also look forward to a rock-climbing wall at the Student Centre on the Thakaneng Bridge, a memorial park for women, residential accommodation within a sports environment, and a botanical garden.

 

Media Release
03 February 2011
Issued by: Lacea Loader
Director: Strategic Communication (actg)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za

 

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