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31 July 2020 | Story Andre Damons | Photo Supplied
Prof Felicity Burt and Prof Paul Grobler from the UFS.

Three scientists from the University of the Free State (UFS), together with authors from other institutions, are part of an international COVID-19 study published in an international peer-reviewed scientific journal recently. 

Prof Paul Grobler, Academic Head of Department: Genetics; Prof Felicity Burt, researcher from the Division of Virology, Faculty of Health Sciences and the NHLS, and SARChI (South African Research Chairs Initiative) Research Chair in vector-borne and zoonotic diseases; as well as Prof Trudy Turner from the University of Wisconsin-Milwauwkee, but also an affiliated professor in the Department of Genetics at the UFS, are co-authors of the paper that appeared in Plos One. The study is titled: ACE2 and TMPRSS2 variation in savanna monkeys (Chlorocebus spp.): Potential risk for zoonotic/anthroponotic transmission of SARS-CoV-2 and a potential model for functional studies.

 The paper follows an initiative of Prof Chris Schmitt at Boston University with researchers affiliated to the University of California, Los Angeles, Rutgers University, the Polish Academy of Sciences, the Ministry of Health of the Russian Federation, the University of Antwerp, the Wake Forest School of Medicine, and the University of Wisconsin-Milwaukee. The team used the opportunity presented by previously sequenced genomes to screen for variation in the genes associated with susceptibility to infection with SARS-CoV-2.

Concerns about animal welfare and conservation issues

Prof Grobler, who has been studying vervet monkeys from a conservation perspective for two decades, says considering the impact of COVID-19 on the country, he feels that any aspect that might potentially help to understand the progression and transmission of the disease, as well as unexpected risks – however small – should be investigated. 
“Since wildlife management is my field, I am of course also concerned about the potential animal welfare and conservation issues involved.  It should, however, be emphasised that while SARS-CoV-2 infection in vervet monkeys has now been shown to be genetically possible, there is no proof of it actually happening in the wild yet.” 

“I am sure that much work on COVID-19 and vervets will follow internationally, but this is the first study to describe variation at the genes linked to susceptibility,” says Prof Grobler. 

Because of his previous work with vervet monkeys in South Africa and further afield, Prof Grobler was invited by Prof Schmitt to contribute to the manuscript.

“I made some suggestions from a conservation perspective, based on my interpretations and also recent international work that have shown that many primate species may be at risk for SARS-CoV-2 infection and are potentially vulnerable to COVID-19. I also felt that some aspects of the paper would be greatly improved with input from a South African expert in zoonotic disease to add to the genetic and conservation perspectives, and I therefore requested that Prof Burt also be approached.”

Potential for non-human primates infection

Prof Burt, whose research interests and expertise include the investigation of viruses of zoonotic origin, and/or those transmitted by mosquitoes and ticks that impact human and/or animal well-being – using a One Health approach – says the study was a collaborative effort between scientists with expertise in a wide range of disciplines, including biological anthropology, genetics, primatology, molecular biology, and virology.

“The concept of One Health encourages collaboration between multiple disciplines, promoting the concept that the interaction between humans, animals, and the environment has an impact on the health of people, animals, plants, and the environment. The outcome is an exciting study that incorporates knowledge from each discipline to investigate the potential susceptibility of non-human primate populations to SARS-CoV-2.” 

“The research suggests that there is potential for novel SARS-CoV-2 to infect non-human primates, and that surveillance of non-human primates living in close proximity to human populations is not only warranted, but is actually important for defining risk to both humans and animals,” says Prof Burt. 

According to her, the majority of recently emerged viruses, including SARS-CoV-2, were zoonotic in origin. The close proximity of humans and wild non-human primates provides potential for cross-species transmission of pathogens; for some endangered species, this could have devastating effects. Similarly, identifying if non-human primates have the potential to act as intermediate hosts for pathogens with significant public health implications, would be important for understanding zoonotic transmission.

“Novel viruses are continually emerging, and we need to be prepared. A multidisciplinary approach to understanding interactions at the wildlife-human interface will be essential for the prevention of future outbreaks.”

News Archive

Master’s student awarded Mandela Rhodes scholarship
2015-11-25

 

Candice Thikeson’s name will be added to the Mandela Rhodes Scholars book
Photo: Valentino Ndaba

Candice Thikeson was recently selected as the only 2016 Mandela Rhodes Scholar from the University of the Free State. She is one of 50 young African postgraduate students, eager to contribute positively to the educational development of the continent.

The Mandela Rhodes scholarship is a fully-funded postgraduate scholarship awarded to promising future leaders by the Mandela Rhodes Foundation. It is named after the former president of our country, Nelson Mandela, and Cecil Rhodes, who was known for his business skills and political influence in South Africa. Instituted in 1999, the scholarship aims to advance scholars who demonstrate the principles of Leadership and Reconciliation embodied by Mandela and Rhodes’s legacy, as they relate specifically to Education and Entrepreneurship.

Thikeson expects the programme will educate her on how to integrate the four pillars in relation to her field of study.

For Thikeson, earning the scholarship served as an endorsement of her dream of becoming an academic. “I want to obtain a PhD, lecture at a university, publish papers, and speak at conferences,” she related. “I also want to produce academics, I want to mentor young people,” she added.

Her academic journey began in 2011 when she pursued a BA Fine Arts degree for a year. Thikeson then transferred to a BA General degree which she completed over two instead of the standard three years. She went on to study an Honours degree in Art History and Visual Culture Studies. In the same year, she travelled to Rijksuniversiteit Groningen (University of Groningen) in the Netherlands as part of an exchange agreement between the university and the UFS, where she completed her mini-dissertation in four months. Both her BA and Honours were passed with distinction. Currently, Thikeson is pursuing a Masters degree at the Department of Art History and Image Studies under the supervision of Prof Suzanne Human.

Some accolades to her name include the Jan Teurlinckx Prize for the best student in Art History (2011), the David Jacobs Prize, awarded to the best student in Philosophy (2013), and the Richard Miles Prize, presented by the Dean of the Faculty of the Humanities (2013). Thikeson was also selected as a member of the Golden Key Honour society in 2012, for her consistent academic excellence.

Last year, Lehlohonolo Mofokeng, Zola Valashiya, and Tumelo Morobane made the UFS proud by graduating as the class of 2015 Mandela Rhodes Scholars.

 

 

 

 

 

 

 

 

 

 

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