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18 June 2020 | Story Nitha Ramnath | Photo Supplied
Mischke Bouwer.

Mischke Bouwer was recently awarded a Fulbright scholarship to study her PhD in Geoscience at the Southern Illinois University (SIU). The duration of the programme at SIU is five years, starting in August 2020.

Fulbright is a scholarship programme that recruits students from all over the world in any field of study to do their postgraduate studies in America. This is done through funding from Fulbright, together with the country's government and American universities. 

“This is not only a funding scholarship, but a supportive community! It really does feel like teamwork so far. The people from Fulbright ensure that the students feel as comfortable and enlightened as possible when leaving the country, and I am sure it will be the same when I arrive in America,” says Mischke.

Mischke considers herself an average girl who grew up in Pretoria; she enrolled at the UFS for a BSc in Geology from 2014 to 2016, followed by an Honours in Geology in 2017, and MSc in Soil Science. 
“I took a big chance by applying for a Fulbright scholarship but did not expect anything, as I felt I would never be good enough – but look where I am now,” says Mischke.

“I am speechless about the scholarship I received. There are many people I would like to thank who helped me along the way to achieve this scholarship. I would love this opportunity to thank all my lecturers from the UFS, both in the departments of Geology and Soil Science. Thanks to my supervisors for always believing in me. A special thanks to Prof Cornie van Huyssteen who was fully behind me, impacting my way of thinking, and teaching me a lot in two years.”

Mischke dedicates this scholarship to the late Prof Marian Tredoux, a true scientist and lecturer in the Department of Geology, who not only contributed greatly to the sciences, but truly impacted her students. “She inspired me to work hard and showed me an example of what a woman in science could be,” says Mischke.

She encourages students to apply for this scholarship, adding that there is nothing to lose. According to Mischke, students are much smarter than they would like to believe and should therefore always be mindful that their future is way brighter than they think.

“Make your role model YOU in 10 years and keep it that way! This way you always have someone to strive for!” says Mischke.

Mischke works on the absorption potential of arsenic and selenium in the field of environmental geochemistry and geochemical modelling. She hopes to return to South Africa with this knowledge and to make a difference in the remediation and rehabilitation of mines. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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